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Tissue Oxygen Utilization in Septic Shock

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Tissue Oxygen Utilization

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 12))

Abstract

The changes of hemodynamic and oxygen transport variables in human septic shock are well documented [1]. They are essentially characterized by a hyperdynamic circulatory state associated with an increased cardiac output (CO), a decreased systemic vascular resistance (SVR) and a narrowed arterial-mixed venous oxygen difference (a-vO2) together with elevated arterial blood lactate levels. Therefore, when arterial oxygenation is maintained, oxygen delivery (DO2) is as a consequence usually supranormal. This implies a defective tissue oxygen extraction as the most important mechanism that limits oxygen consumption (\( \dot{V}{{O}_{2}} \)) in septic shock. Throughout a septic episode the basic pathophysiologic problem seems to be a disparity between the uptake of oxygen and the demand of oxygen in the tissues as manifested by increased blood lactate levels. Limitation of oxygen uptake may significantly contribute to morbidity and mortality by predisposing to multiple organ failure. Several observations suggest that inadequate tissue oxygenation is a central mechanism mediating the widespread and irreversible tissue damage that is associated with multiple organ failure and a fatal outcome [2, 3].

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Authors
  1. L. G. Thijs
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  2. A. B. J. Groeneveld
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Editors and Affiliations

  1. Pulmonary Medicine, Health Science Center, 6431 Fannin, Suite 1274, 77030, Houston, TX, USA

    Guillermo Gutierrez

  2. Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Route de Lennik 808, 1070, Brussels, Belgium

    Jean Louis Vincent (Clinical Director) (Clinical Director)

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Thijs, L.G., Groeneveld, A.B.J. (1991). Tissue Oxygen Utilization in Septic Shock. In: Gutierrez, G., Vincent, J.L. (eds) Tissue Oxygen Utilization. Update in Intensive Care and Emergency Medicine, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84169-9_16

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  • DOI: https://doi.org/10.1007/978-3-642-84169-9_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-52472-4

  • Online ISBN: 978-3-642-84169-9

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