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RecBCD Enzyme

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Nucleic Acids and Molecular Biology 4

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 4))

Abstract

RecBCD enzyme, also called exonuclease V (EC 3.1.11.5), is unusual among nucleases in its requirement for ATP. This large, three subunit enzyme has multiple enzymatic activities and plays important roles in many aspects of DNA metabolism, including recombination, repair and replication. Although the Escherichia coli RecBCD enzyme has been the most thoroughly investigated one, RecBCD-like enzymes have been reported from many bacterial species, both gram-negative and gram-positive (reviewed by Muskavitch and Linn 1981; see also Schultz and Smith 1986; McKittrick and Smith 1989). In this review I describe RecBCD enzyme’s activities and discuss how these activities may participate in cellular DNA metabolism. For a more extensive review and additional references see Taylor (1988).

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  1. Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, WA, 98104, USA

    G. R. Smith

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  1. G. R. Smith
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  1. Abteilung Chemie, Max-Planck-Institut für experimentelle Medizin, Hermann-Rein-Straße 3, D-3400, Göttingen, Germany

    Fritz Eckstein

  2. Biochemistry Department, University of Dundee, GB-Dundee, DD1 4HN, UK

    David M. J. Lilley

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Smith, G.R. (1990). RecBCD Enzyme. In: Eckstein, F., Lilley, D.M.J. (eds) Nucleic Acids and Molecular Biology 4. Nucleic Acids and Molecular Biology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84150-7_5

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  • DOI: https://doi.org/10.1007/978-3-642-84150-7_5

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