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Surface Linking and Helical Repeat of Protein-Wrapped DNA

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Nucleic Acids and Molecular Biology 4

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 4))

Abstract

The binding of closed circular DNA to proteins involves significant alterations in both the secondary and tertiary structure of the DNA. The effects on the DNA secondary structure are often manifested by the formation of bends or kinks, as well as by changes in the helical repeat or other duplex winding parameter. The effects on the DNA tertiary structure can be either local or global in nature. For example, the tertiary structure can change locally as a consequence of wrapping of a portion of the DNA on a protein surface. More generally, global DNA tertiary structural alterations can arise as a consequence of the requirement that the linking number remain constant as long as the topological constraint is maintained. As a result, the three-dimensional configuration of the DNA axis may be significantly altered compared to a DNA that is topologically unconstrained.

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Author information

Authors and Affiliations

  1. Department of Microbiology, School of Medicine, State University of New York, Stony Brook, NY, 11794, USA

    W. R. Bauer

  2. Department of Mathematics, University of California, Los Angeles, CA, 90024, USA

    J. H. White

Authors
  1. W. R. Bauer
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  2. J. H. White
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Editor information

Editors and Affiliations

  1. Abteilung Chemie, Max-Planck-Institut für experimentelle Medizin, Hermann-Rein-Straße 3, D-3400, Göttingen, Germany

    Fritz Eckstein

  2. Biochemistry Department, University of Dundee, GB-Dundee, DD1 4HN, UK

    David M. J. Lilley

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© 1990 Springer-Verlag Berlin Heidelberg

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Bauer, W.R., White, J.H. (1990). Surface Linking and Helical Repeat of Protein-Wrapped DNA. In: Eckstein, F., Lilley, D.M.J. (eds) Nucleic Acids and Molecular Biology 4. Nucleic Acids and Molecular Biology, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84150-7_3

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  • DOI: https://doi.org/10.1007/978-3-642-84150-7_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84152-1

  • Online ISBN: 978-3-642-84150-7

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