Abstract
Despite the development of several new antifungal drugs, intravenous amphotericin B (amB) is still considered the drug of choice for the treatment of severe systemic fungal infections in immunocompromised patients. However, therapy is often limited by various side effects (Table 1). From the patients’ point of view, the acute toxic reactions (fever, chills, nausea and vomiting) induced by the drug are particularly troublesome.
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References
Campbell GD (1982) Using amphotericin B. Intern Med 3: 95–102
Fields BT, Bates JH, Abernathy RS (1971) Effect of rapid intravenous infusion on serum concentrations of amphotericin B. Appl Microbiol 22: 615–617
Loomer L, Cruz J, Powell B, Capizzi R, Peacock J (1988) Rapid intravenous (iv) infusion of amphotericin B ( AmB) (abstract ). Proc ASCO 7: 285
Seabury JH, Dascomb HE (1958) Experience with amphotericin B for the treatment of systemic mycoses. Arch Intern Med 102: 960–976
Spitzer TR, Creger RJ, Fox RM, Lazarus HM (1989) Rapid infusion amphotericin B: effective and well-tolerated therapy for neutropenic fever. Pharmatherapeutica 5: 305–311
Utz JP, Bennett JE, Brandriss MW, Butler T, Hill GJ (1964) Amphotericin B toxicity. Ann Intern Med 61: 334–354
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© 1991 Springer-Verlag Berlin · Heidelberg
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Arning, M., Dresen, B., Aul, C., Schneider, W. (1991). Influence of Infusion Time on the Acute Toxicity of Amphotericin B: Results of a Randomized Double-Blind Study. In: Senn, HJ., Glaus, A. (eds) Supportive Care in Cancer Patients II. Recent Results in Cancer Research, vol 121. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84138-5_41
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DOI: https://doi.org/10.1007/978-3-642-84138-5_41
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