Recombinant Human Interleukin-3 in Patients with Hematopoietic Failure

  • A. Ganser
  • A. Lindemann
  • G. Seipelt
  • O. G. Ottmann
  • M. Eder
  • F. Herrmann
  • J. Frisch
  • G. Schulz
  • R. Mertelsmann
  • D. Hoelzer
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 121)

Abstract

Infections and bleeding are the most frequent causes of death in patients with bone marrow failure secondary to chemotherapy and/or radiotherapy for malignant disease. Treatment of anemia and severe thrombocytopenia has hitherto depended solely on red blood cell and platelet transfusion. With the recent availability of recombinant hematopoietic colony-stimulating factors (CSFs), stimulation of hematopoiesis in vivo has evolved as a new, potentially efficacious treatment modality. The feasibility of this approach is supported by several clinical studies showing that two distinct CSFs, granulocyte-macrophage CSF (GM-CSF) and granulocyte CSF (G-CSF), can indeed elevate total leukocyte counts in patients with bone marrow failure [1–14]. However, improvements in erythropoiesis and thrombopoiesis were observed only sporadically [2, 6, 7, 8].

Keywords

Toxicity Lymphoma Leukemia Pneumonia Anemia 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1991

Authors and Affiliations

  • A. Ganser
    • 1
  • A. Lindemann
    • 2
  • G. Seipelt
    • 1
  • O. G. Ottmann
    • 1
  • M. Eder
    • 1
  • F. Herrmann
    • 2
  • J. Frisch
    • 3
  • G. Schulz
    • 3
  • R. Mertelsmann
    • 2
  • D. Hoelzer
    • 1
  1. 1.Abteilung für Hämatologie, Zentrum der Inneren MedizinKlinikum der Johann Wolfgang Goethe-UniversitätFrankfurt 70Germany
  2. 2.Abteilung Hematologie-OnkologieMedizinische UniversitätsklinikFreiburgGermany
  3. 3.Klinische ForschungBehringwerke AGMarburgGermany

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