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Supportive Care in Cancer Patients II pp 121–140Cite as

Cytokines and Hematopoietins: Physiology, Pathophysiology, and Potential as Therapeutic Agents

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 121))

Abstract

Improved understanding of host biology, immunology, and tumor pathophysiology raises the possibility of introducing new treatment modalities for cancer patients: stimulation of host defense mechanisms, including specific and nonspecific immunological approaches, as well as approaches aimed directly at altering tumor growth and differentiation by therapeutically influencing pathophysiological mechanisms. In addition, amelioration of cancer and cancer treatment-associated morbidity offers new possibilities for improving the quality of life for many patients, as well as options for increased dose-intensity regimens, with the potential of achieving higher cure rates in some patient groups. In this chapter we will focus on insights gained into the in vivo physiology of human cytokines and on the experience gained so far with the use of cytokines in cancer therapy.

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  1. Abteilung Innere Medizin I-Hämatologie/Onkologie, Medizinische Universitatsklinik, Hugstetter Straße 55, W-7800, Freiburg, Germany

    R. Mertelsmann, F. M. Rosenthal, A. Lindemann & F. Herrmann

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  1. Medizinische Klinik C, Kantonsspital St. Gallen, 9007, St. Gallen, Switzerland

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Mertelsmann, R., Rosenthal, F.M., Lindemann, A., Herrmann, F. (1991). Cytokines and Hematopoietins: Physiology, Pathophysiology, and Potential as Therapeutic Agents. In: Senn, HJ., Glaus, A. (eds) Supportive Care in Cancer Patients II. Recent Results in Cancer Research, vol 121. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84138-5_15

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