Abstract
Many agents used as antiemetics induce severe side-effects. This paradox reduces the rate at which we can control cancer chemotherapy-induced nausea and vomiting. We need more effective agents and combinations thereof in this fight for a major goal in the quality of life of our patients. Indeed, total and not partial control of emesis is considered by most patients as the only clearly significant benefit from antiemetic treatment [1]. Should this goal not be achieved, many patients prefer antiemetic treatment giving minimal side-effects, such as with corticosteroids [2] or the recently developed serotonin (5HT3) receptor antagonists.
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References
Bennett JM, Byrne P et al. (1985) A randomized multicenter trial of cyclophosphamide, novantrone and 5-fluorouracil (CNF) versus cyclophosphamide, adriamycin and 5-fluorouracil ( CAF) in patients with metastatic breast cancer. Invest New Drugs 3: 179–185
Aapro MS, Plezia PM et al. (1984) Double-blind crossover study of the antiemetic efficacy of high-dose dexamethasone versus high-dose metoclopramide. J Clin Oncol 2: 466–471
Borison HL, McCarthy LE (1983) Neuropharmacology of chemotherapy-induced emesis. Drugs 25 [Suppl 1]: 8–17
Akwari OE (1983) The gastrointestinal tract in chemotherapy-induced emesis. A final common pathway. Drugs 25 [Suppl I]: 18–34
Peroutka SJ, Synder SH (1982) Antiemetics: neurotransmitter receptor binding predicts therapeutic actions. Lancet is 658
Bakowski MT (1984) Advances in anti-emetic therapy. Cancer Treat Rev 11: 237–256
Joss R, Galeazzi R et al. (1981) Nausea and Erbrechen bei der Chemotherapie maligner Tumoren. Schweiz Med Wochenschr 111: 1614–1622
Pater JL, Willan AR (1984) Methodologic issues in trials of antiemetics. J Clin Oncol 2: 484–487
Olver IN, Simon RM, Aisner J (1986) Antiemetic studies: a methodological discussion. Cancer Treat Rep 70: 555–563
Morrow GR (1982) Prevalence and correlates of anticipatory nausea and vomiting in chemotherapy patients. J Natl Cancer Inst 68: 585–588
Parliament MB, Danjoux CE et al. (1985) Is cancer treatment toxicity accurately reported? Int J Radiat Oncol Biol Phys 11: 603–608
Winokur SM, Baker JJ et al. (1981) Dexamethasone in the treatment of nausea and vomiting from cancer chemotherapy. J Med Assoc Ga 70: 263–264
Baker JJ, Lockey JL et al. (1979) Nabilone as an antiemetic. N Engl J Med 301: 728
Rich NM, Abdulhayoglu G, Disaia RI (1980) Methylprednisolone as an antiemetic during cancer chemotherapy—a pilot study. Gynecol Oncol 9: 193–198
Lee BJ (1981) Methylprednisolone as an antiemetic. N Engl J Med 304: 486 (letter)
Aapro MS, Alberts DS (1981) High-dose dexamethasone for prevention of cisplatininduced vomiting. Cancer Chemother Pharmacol 7: 11–14
Morrow GR, Morrel C (1982) Behavioral treatment for the anticipatory nausea and vomiting induced by cancer chemotherapy. N Engl J Med 307: 1476–1480
Breau JL, Israel L et al. (1983) Efficacité de la méthylprednisolone dans la prévention des vomissements dus aux chimiothérapies par sels de platine dans un essai randomisé. Presse Med 12: 2058
Cassileth PA, Lusk EJ et al. (1983) Antiemetic efficacy of dexamethasone therapy in patients receiving cancer chemotherapy. Arch Intern Med 43: 1347–1349
Kolaric K, Roth A (1983) Methylprednisolone as an antiemetic in patients on cisplatinium chemotherapy. Results of a controlled randomized study. Tumori 69: 43–46
Cognetti F, Pinnaro P et al. (1984) Randomized open cross-over trial between metoclopramide (MCP) and dexamethasone ( DXM) for the prevention of cisplatininduced nausea and vomiting. Eur J Cancer Clin Oncol 20: 183–187
Giaccone G, Donadio M et al. (1984) Comparison of the antiemetic effect of high-dose intravenous metoclopramide in the prophylactic treatment of cis-platin-induced nausea and vomiting. Tumori 70: 237–241
Markman M, Sheider V et al. (1984) Antiemetic efficacy of dexamethasone. Randomized, double-blind, crossover study with prochlorperazine in patients receiving cancer chemotherapy. N Engl J Med 311: 549–552
Dana BW, Everts EC, Dickison D (1985) Dexamethasone vs placebo for cisplatininduced emesis. A randomized cross-over trial. Am J Clin Oncol 8: 426–428
D’Olimpio JT, Camacho F et al. (1985) Antiemetic efficacy of high-dose dexamethasone versus placebo in patients receiving cisplatin-based chemotherapy: a randomized double-blind controlled clinical trial. J Clin Oncol 3: 1133–1136
Frustaci S, Grattoni E et al. (1986) Randomized crossover antiemetic study in cisplatin-treated patients. Comparison between high-dose i.v. metoclopramide and high-dose i.v. dexamethasone. Cancer Chemother Pharmacol 17: 75–79
Ibrahim EM, Al-Idrissi HY et al. (1986) Antiemetic efficacy of high-dose dexamethasone: randomized, double-blind, crossover study with high-dose metoclopramide in patients receiving cancer chemotherapy. Eur J Cancer Clin Oncol 39: 619–624
Shinkai T, Saijo N et al. (1986) Antiemetic efficacy of high-dose intravenous metoclopramide and dexamethasone in patients receiving cisplatin-based chemotherapy: a randomized controlled trial. Jpn J Clin Oncol 16: 279–287
Niijima T, Isurugi K et al. (1986) Randomized cross-over study on the effects of methylprednisolone, metoclopramide and droperidol on the control of nausea and vomiting associated with cis-platinum chemotherapy. Gan To Kagaku Ryoho 13: 2376–2382
Chiara S, Scarsi P et al. (1984) Low dose metoclopramide versus methylprednisolone in controlling chemotherapy induced nausea and vomiting. Chemotherapia 3: 333–336
Campora E, Chiara S et al. (1985) The antiemetic efficacy of methylprednisolone compared with metoclopramide in outpatients receiving adjuvant CMF chemotherapy for breast cancer: a randomized trial. Tumori 71: 459–462
Giaccone G, Donadio M et al. (1984) Comparison of methylprednisolone and metoclopramide in the prophylactic treatment of cis-platin-induced nausea and vomiting. Tumori 70: 237–241
Osoba D, Erlichman C et al. (1986) Superiority of methylprednisolone sodium succinate over low dose metoclopramide hydrochloride in the prevention of nausea and vomiting produced by cancer chemotherapy. Clin Invest Med 9: 225–231
Metz CA, Freedman RS et al. (1987) Methylprednisolone in cis-platinum induced nausea and emesis: a placebo-controlled trial. Gynecol Oncol 27: 84–89
Martin Jimenez M, Diaz-Rubio E (1986) Atlas dosis de metilpredinisolona como tratamiento antiemético adyuvante de la metoclopramida en los vómitos inducidos por cisplatino. Resultados de un estudio controlado. Neoplasia 3: 61–63
Cunningham D, Evans C et al. (1987) Comparison of antiemetic efficacy of domperidone, metoclopramide, and dexamethasone in patients receiving outpatient chemotherapy regimens. Br Med J 295: 250
Roila F, Tonato M et al. (1987) Double-blind controlled trial of the antiemetic efficacy and toxicity of methylprednisolone (MP), metoclopramide (MTC) and domperidone (DMP) in breast cancer patients treated with i.v. CMF. Eur J Cancer Clin Oncol 23: 615–617
Al-Idrissi HY, Ibrahim EM et al. (1988) Antiemetic efficacy of high-dose dexamethasone: randomized, double-blind, crossover study with a combination of dexamethasone, metoclopramide and diphenhydramine. Br J Cancer 57: 308–312
Basurto C, Roila F et al. (1988) A double-blind trial comparing antiemetic efficacy and toxicity of metoclopramide versus methylprednisolone versus domperidone in patients receiving doxorubicin chemotherapy alone or in combination with other antiblastic agents. Am J Clin Oncol 11: 594–596
Roila F, Basurto C et al. (1988) Methylprednisolone versus metoclopramide for prevention of nausea and vomiting in breast cancer patients treated with intravenous cyclophosphamide methotrexate 5-fluorouracil: a double-blind randomized study. Oncology 45: 346–349
Goldstein D, Levi JA, Woods RL et al. (1989) Double-blind randomized cross-over trial of dexamethasone and prochlorperazine as anti-emetics for cancer chemotherapy. Oncology 46: 105–108
Pollera CF, Nardi M, Marolla Petal. (1989) Effective control of CMF-related emesis with high-dose dexamethasone: results of a double-blind crossover trail with metoclopramide and placebo. Am J Clin Oncol 12: 524–529
Strum SB, Mc Dermed JE et al. (1985) High-dose intravenous metoclopramide versus combination high-dose metoclopramide and intravenous dexamethasone in preventing cisplatin-induced nausea and emesis: a single-blind crossover comparison of antiemetic efficacy. J Clin Oncol 3: 245–251
Poilera CF, Nardi M et al. (1987) A randomized trial comparing alizapride alone or with dexamethasone vs a metoclopramide-dexamethasone combination for emesis induced by moderate-dose cisplatin. Cancer Chemother Pharmacol 19: 335–338
Gathercole F, Connolly N, Birdsell J (1982) The use of dexamethasone (hexadrol) as an antiemetic in association with chemotherapy for neoplastic disease. Oncol Nurs Forum 9: 17–19
Bruera E, Roca E et al. (1986) Improved control of chemotherapy induced emesis by the addition of dexamethasone to metoclopramide in patients resistant to metoclopramide. Cancer Treat Rep 67: 381–383
Colbert N, Izrael V et al. (1983) Adrenocorticotropic hormone in the prevention of cisplatin—induced nausea and vomiting. J Clin Oncol 1: 635–639
Allan SG, Cornbleet MA et al. (1984) Dexamethasone and high-dose metoclopramide efficacy in controlling cisplatin-induced nausea and vomiting. Br Med J 289: 878–879
Donovitz GS, O-Quinn AG et al. (1984) Antiemetic efficacy of high-dose corticosteroids and droperidol and metoclopramide. Gynecol Oncol 18: 320–325
Panza N, de Cesare M et al. (1984) Methylprednisolone and chlorpromazine alone or in combination for the control of cisplatin-induced emesis. Cancer Treat Rep 68: 1310–1311
Benrubi GI, Norvell M et al. (1985) The use of methylprednisolone and metoclopramide in control of emesis in patients receiving cis-platinum. Gynecol Oncol 21: 306–313
Ell C, Konig HJ et al. (1985) Antiemetic efficacy of moderately high-dose metoclopramide in patients receiving varying doses of cisplatin. Controlled comparison with a combination of methylprednisolone and metoclopramide. Oncology 42: 354–357
Becouarn Y, Nguyen B et al. (1986) Improved control of cisplatin-induced emesis with a combination of high doses of methylprednisolone and metoclopramide: a single-blind randomized trial. Eur J Cancer Oncol 22: 1421–1424
Fujii M, Kiura K et al. (1986) Randomized crossover trial of the antiemetic effects obtained with metoclopramide and droperidol versus those obtained with metoclopramide, droperidol and methylprednisolone in patients receiving cis-platinum chemotherapy. Gan To Kagaku Ryoho 13: 2562–2567
Rhinehart SN, Dugan WM et al. (1986) The value of dexamethasone when added to combination drug therapy in the prevention of cisplatin-induced nausea and vomiting, evaluated by time-lapse video technology. Prog Clin Biol Res 216: 407–416
Senn HJ, Kohler M et al. (1986) Prevention of nausea and emesis during cytostatic therapy. Antiemetic efficacy of high-dosage oral metoclopramide without and with prednisone. Dtsch Med Wochenschr 11: 129–135
Shinkai T, Saijo N et al. (1986) Antiemetic efficacy of high-dose intravenous metoclopramide and dexamethasone in patients receiving cisplatin-based chemotherapy: a randomized controlled trial. Jpn J Clin Oncol 6: 279–287
Grunberg SM, Akerley WL et al. (1986) Comparison of metoclopramide and metoclopramide plus dexamethasone for complete protection from cisplatinuminduced emesis. Cancer Invest 4: 379–385
Roila F, Tonato M et al. (1987) Antiemetic activity of high doses of metoclopramide combined with methylprednisolone versus metoclopramide alone in cisplatin-treated cancer patients: a randomized double-blind trial of the Italian Oncology Group for Clinical Research. J Clin Oncol 5: 141–149
Giaccone G, Bertetto O et al. (1988) High doses of methylprednisolone with or without alizapride in the prevention of cisplatin-induced emesis. A randomized, double-blind, crossover study. Oncology 45: 74–78
Martin Jiménez M, Diaz-Rubio E (1986) Actividad antiemetica de las altas dosis de metilprednisolona intravenosa en los vomitos inducicos por quimioterapia antineoplastica. Resultados de un estudio controlado. An Med Intern (Madr) 11: 525–528
Gez E, Brufman G, Kaufman B et al. (1989) Methylprednisolone and chlorpromazine in patients receiving cancer chemotherapy: a prospective non-randomized study. J Chemother 1: 140–143
Basurto C, Roila F, Tonato M et al. (1989) Antiemetic activity of high-dose metoclopramide combined with methylprednisolone versus metoclopramide alone in dacarbazine-treated cancer patients. A randomized double-blind study of the Italian Oncology Group for Clinical Research. Am J Clin Oncol 12: 235–238
Carmichael J, Cantwell BMJ, Edwards CM, Rapeport WG, Harris AL (1988) The serotonin type 3 receptor antagonist BRL 43694 and nausea and vomiting induced by cisplatin. Br Med J 297: 110–111
Cunningham D, Turner A, Hawthorn J et al. (1989) Ondansetron with and without dexamethasone to treat chemotherapy-induced emesis. Lancet is 1323
Roila F, Tonato M, Cognetti F et al. (1990) A double-blind multicentre randomized crossover study comparing the antiemetic efficacy and tolerability of ondansetron (OND) vs OND plus dexamethasone (DEX) in cisplatin (CDDP) treated cancer patients (PTS). Presented at the 2nd International Symposium on Supportive Care, St Gallen (this volume)
Ise T, Ohira A et al. (1982) Clinical evaluation of antiemetics for vomiting due to cancer chemotherapy in children. Gan To Kagaku Ryoho 9: 1108–1118
Mehta P, Gross S et al. (1986) Methylprednisolone for chemotherapy-induced emesis: a double-blind randomized trial in children. J Pediatr 108: 774–776
Marshall G, Kerr S, Vowels M et al. (1989) Antiemetic therapy for chemotherapy-induced vomiting: metoclopramide, benzotropine, dexamethasone, and lorazepam regimen compared with chlorpromazine alone. J Pediatr 115: 156–160
Matsumoto I, Aikawa T, Kanda T et al. (1989) Amelioration of cisplatin-induced vomiting and anorexia by methylprednisolone. Gan To Kagaku Ryoko 16: 833–838
Bloom BS (1989) Risk and cost of gastrointestinal side effects associated with nonsteroidal anti-inflammatory drugs. Arch Intern Med 149: 1019–1022
Levitt M, Sharma RN et al. (1979) Normal metyrapone response after 1 month of high-dose methylprednisolone in cancer patients: a phase I study. Cancer Treat Rep 63: 1327–1330
Haid M (1981) Steroid antiemesis may be harmful. N Engl J Med 304: 1237
Grunewald HW, Rosner F (1984) Dexamethasone as an antiemetic during cancer chemotherapy. Ann Intern Med 101: 398
Aapro MS, Alberts DS, Serokman R (1983) Lack of dexamethasone effect on the antitumor activity of cisplatin. Cancer Treat Rep 67: 1013–1017
Baharav E, Harpaz D et al. (1986) Dexamethasone-induced perineal irritation. N Engl J Med 314: 515
Allan SG, Leonard RCF (1986) Dexamethasone antiemesis and side-effects. Lancet is 1035
Thomas VL (1986) More on dexamethasone-induced perineal irritation. N Engl J Med 314: 1643
Palmer MC, Colls BM (1987) Amelioration of cytotoxic-induced emesis with high-dose metoclopramide, dexamethasone and lorazepam. Cancer Chemother Pharmacol 19: 331–334
Bluming AZ, Zeegen P (1986) Cataracts induced by intermittent decadron used as an antiemetic. J Clin Oncol 4: 221–223
Demuynck B, Gramont A, de Gonzalez-Cavalli G et al. (1989) Randomized trial of sustained-release ACTH versus sustained-release ACTH and metoclopramide for the prevention of emesis induced by cyclophosphamide-adriamycin-5FU chemotherapy (in french). Semin Hôp Paris 65: 1742–1744
Stephen LC, Rine J et al. (1981) The role of prostaglandins in the excessive nausea and vomiting after intravascular cis-platinum therapy. Gynecol Oncol 12: 89–91
Livera P, Trojano M, Simone IL et al. (1985) Acute changes in blood CSF barrier permselectivity to serum proteins after intrathecal methotrexate and CNS irradiation. J Neurol 231: 336–339
Harris AL (1982) Cytotoxic-therapy-induced vomiting is mediated via enkephalin pathways. Lancet is 714
Drapkin RL, Sokl GH et al. (1982) The antiemetic effect and dose response of dexamethasone in patients receiving cis-platinum. Proc Am Soc Clin Oncol 1: 64 (abstr)
Chiara S, Campora E et al. (1987) Methylpredinisolonè for the control of CMFinduced emesis. Am J Clin Oncol 10: 264–267
Kessler JF, Alberts DS et al. (1986) An effective five-drug antiemetic combination for prevention of chemotherapy-related nausea and vomiting. Experience in eighty-four patients. Cancer Chemother Pharmacol 17: 282–286
Kris MG, Richard JG et al. (1985) Improved control of cisplatin-induced emesis with high-dose metoclopramide and with combinations of metoclopramide, dexamethasone, and diphenhydramine. Results of consecutive trials in 255 patients. Cancer 55: 527–534
Kris MG, Gralla RJ, Tyson LB et al. (1989) Controlling delayed vomiting: double-blind, randomized trial comparing placebo, dexamethasone alone, and metoclopramide plus dexamethasone in patients receiving cisplatin. J Clin Oncol 7: 108–114
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© 1991 Springer-Verlag Berlin · Heidelberg
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Aapro, M.S. (1991). Present Role of Corticosteroids as Antiemetics. In: Senn, HJ., Glaus, A. (eds) Supportive Care in Cancer Patients II. Recent Results in Cancer Research, vol 121. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84138-5_11
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DOI: https://doi.org/10.1007/978-3-642-84138-5_11
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