Update 1990 pp 269-276 | Cite as

Pulmonary Hypertension in Bronchopulmonary Dysplasia

  • P. Daoud
  • F. Beaufils
  • J.-F. Hartmann
Conference paper
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 10)


Bronchopulmonary dysplasia (BPD) was first described by Northway et al. in 1967 [1]: it is a sequela of variable duration of the respiratory distress syndrome of the newborn and particularly of the premature, whose lungs are deficient in surfactant at birth. In most cases BPD evolves toward a full normalization of the pulmonary function within a few months to two years. Some patients, however, remain in severe respiratory insufficiency leading to fatal outcome in the absence of prolonged mechanical ventilation and oxygen therapy [2]: most of these patients have pulmonary hypertension.


Pulmonary Hypertension Patent Ductus Arteriosus Pulmonary Artery Pressure Oxygen Therapy Chronic Hypoxia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Northway WH Jr, Rosan RC, Porter DY (1967) Pulmonary disease following respiratory therapy of hyaline membrane disease. N Engl J Med 276:357–368PubMedCrossRefGoogle Scholar
  2. 2.
    Hartmann JF, Beaufils F, Vervel C (1987) Facteurs pronostiques dans les formes graves de dysplasies bronchopulmonaires. Arch Fr Pediatr 44:423–431PubMedGoogle Scholar
  3. 3.
    Harrod JR, L’Heureux P, Douglas Wangensteen O, Hunt CO (1974) Long term follow up of severe repiratory distress syndrome treated with IPPB. J Pediatr 84:277–286PubMedCrossRefGoogle Scholar
  4. 4.
    Fouron JC, Leguennec JC, Villemant D, et al (1980) Value of echocardiography in assessing the outcome of bronchopulmonary dysplasia. Pediatrics 65:529–535PubMedGoogle Scholar
  5. 5.
    Abman SH, Wolfe RR, Accurso FJ, et al (1985) Pulmonary vascular response to oxygen in infants with severe bronchopulmonary dysplasia. Pediatrics 75:80–84PubMedGoogle Scholar
  6. 6.
    Berman W Jr, Katz R, Yabek SM, et al (1982) Evaluation of infants with bronchopulmonary dysplasia using cardiac catheterization. Pediatrics 70:708–712PubMedGoogle Scholar
  7. 7.
    Goodman G, Perkin RM, Anas NG, et al (1988) Pulmonary hypertension in infants with bronchopulmonary dysplasia. J Pediatr 112:67–72PubMedCrossRefGoogle Scholar
  8. 8.
    Reid LM (1979) The pulmonary circulation: remodeling in growth and disease. Am Rev Respir Dis 119:531–546PubMedGoogle Scholar
  9. 9.
    Bonikos AS, Bensch KG, Northway WH Jr, Adwards DK (1976) Bronchopulmonary dysplasia: the pulmonary pathologic sequel of necrotizing bronchiolitis and pulmonary fibrosis. Hum Pathol 77:643–665CrossRefGoogle Scholar
  10. 10.
    Stocker JT (1986) Pathologic features of long standing “healed” bronchopulmonary dysplasia: a study of 28 to 40 months old infants. Human Pathol 17:943–961CrossRefGoogle Scholar
  11. 11.
    Thurlbeck WM (1979) Morphologic aspects of bronchopulmonary dysplasia. J Pediatr 95:842–843PubMedCrossRefGoogle Scholar
  12. 12.
    Reid L (1979) Bronchopulmonary dysplasia pathology. J Pediatr 93:836–840Google Scholar
  13. 13.
    Heath D, Edward JE (1958) The pathology of hypertensive pulmonary vascular disease. Description of 6 grades of structural changes in alveolous arteries with special reference to congenital cardiac defect. Circulation 18:533PubMedGoogle Scholar
  14. 14.
    Kay JM (1980) Effect of intermittent normoxia on chronic hypoxic pulmonary hypertension, right ventricular hypertrophia and polycythemia in rats. Am Rev Respir Dis 121:993–1001PubMedGoogle Scholar
  15. 15.
    Kay JM, Suyama KL, Keane PM (1981) Effect of intermittent normoxia on muscularization of pulmonary arterioles induced by chronic hypoxemia in rats. Am Rev Respir Dis 122:454–459Google Scholar
  16. 16.
    NOTT Group (1980) Continuous or nocturnal oygen therapy in hypoxemic chronic obstructive lung disease. Ann Intern Med 93:391–398Google Scholar
  17. 17.
    Timms RM, Fhaja FU, Williams GW, the NOTT (1985) Hemodynamic response to oxygen therapy in chronic obstructive pulmonary disease. Ann Intern Med 102:29–36PubMedGoogle Scholar
  18. 18.
    Gaultier C, Praud JP, Clement AD, et al (1985) Respiration during sleep in children with COPD. Chest 7:168–173CrossRefGoogle Scholar
  19. 19.
    Thibeault DW, Beatty EP, Hall RT, Bowen SK (1985) Neonatal pulmonary hypoplasia with premature rupture of fetal membrane and oligoamnios. J Pediatr 107:73–77Google Scholar
  20. 20.
    Berman W Jr, Katz R, Yabek SM, et al (1986) Long term follow up of bronchopulmonary dysplasia. J Pediatr 109:45–50PubMedCrossRefGoogle Scholar
  21. 21.
    Hirshfeld S, Meyer R, Schwartz DC, et al (1975) The echographic assessment of pulmonary artery pressure and pulmonary vascular resistance. Circulation 52:642–649Google Scholar
  22. 22.
    Perez D, Azancot A, Lamberti A (1985) Hypertension artérielle pulmonaire chez l’enfant; Evaluation quantitative par échocardiographie-Doppler puisé. Congrès Français d’Echocardiographie. ParisGoogle Scholar
  23. 23.
    Kitabake A, Inoue M, Asaq M, et al (1983) Non-invasive evaluation of pulmonary hypertension by a pulsed Doppler technique. Circulation 68:302–309CrossRefGoogle Scholar
  24. 24.
    Marchandise B, De Bruyne B, Delaunois L, Kremer R (1987) Non-invasive prediction of pulmonary hypertension in chronic obstructive pulmonary disease by Doppler echocardiography. Chest 91:361–364PubMedCrossRefGoogle Scholar
  25. 25.
    Masuyama T, Koama K, Kitabake A, et al (1986) Continuous wave Doppler echocardiographic detection of pulmonary regurgitation and its application to non-invasive estimation of pulmonary artery pressure. Circulation 74:484–492PubMedCrossRefGoogle Scholar
  26. 26.
    Weinstein MR (1981) Oxygen consumption in infants with bronchopulmonary dysplasia. J Pediatr 99:958–961PubMedCrossRefGoogle Scholar
  27. 27.
    Wolfson MR, Bhutan VK, Shaffer TH, Bowen FW (1984) Mechanics and energetics of breathing helium in infants with bronchopulmonary dysplasia. J Pediatr 104:752–757PubMedCrossRefGoogle Scholar
  28. 28.
    Kurzner SI, Garg M, Bautista DB, et al (1988) Growth failure in bronchopulmonary dysplasia: Elevated metabolic rates and pulmonary mechanics. J Pediatr 112:73–80PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • P. Daoud
  • F. Beaufils
  • J.-F. Hartmann

There are no affiliations available

Personalised recommendations