Atrophy of Thymus Induced by Cytostatic Chemicals, Rat

  • Kiyoshi Imai
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


The weight of an affected thymus decreases, because of atrophy. The color of the thymus is normal, but occasionally has increased opacity. Sometimes hemorrhagic foci are noted, especially in the medulla. In advanced cases, the thymus cannot be distinguished from the surrounding adipose tissue.


Advanced Case Thymic Epithelial Cell Thymic Atrophy Thymic Weight Thymic Lymphocyte 
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  1. Dersham G, McMartin D, Dunber D, Kaminsky L (1983) Trifluorinated ether anesthetic lethality in rats : the role of bacterial infection. Toxicol Appl Pharmacol 71: 93–100PubMedCrossRefGoogle Scholar
  2. Gupta BN, McConnell EE, Goldstein JA, Harris MW, Moore JA (1983) Effects of a polybrominated biphenyl mixture in the rat and mouse. I. Six-month exposure. Toxicol Appl Pharmacol 68: 1–18PubMedCrossRefGoogle Scholar
  3. Meihuizen SP, Burek JD (1978) The epithelial cell component of the thymuses of aged female BN/Bi rats. A light microscopic electron microscopic and autoradiographic study. Lab Invest 39: 613–622PubMedGoogle Scholar
  4. Miller RR, Carreon RE, Young JT, McKenna JM (1982) Toxicity of methoxyacetic acid in rats. Fundam Appl Toxicol 2: 158–160PubMedCrossRefGoogle Scholar
  5. Olson LJ, Hsai MT, Kreamer BL, Hinsdill RD (1984) Immunosuppression in weanling and adult Sprague-Dawley rats induced by acute exposure to 3,3′,4,4′-tetrachloroazobenzene. Toxicology 32: 287–296PubMedCrossRefGoogle Scholar
  6. Snoeij NJ, van Iersel AAJ, Penninks AH, Seinen W (1985) Toxicology of triorganotin compounds : comparative in vivo studies with a series of trialkyltin compounds and triphenyltin chloride in male rats. Toxicol Appl Pharmacol 81: 274–286PubMedCrossRefGoogle Scholar
  7. Tonelli G (1966) Acute toxicity of corticosteroids in the rat. Toxicol Appl Pharmacol 8: 250–258PubMedCrossRefGoogle Scholar
  8. van Logten MJ, Gupta BN, McConnell EE, Moore JA (1980) Role of the endocrine system in the action of 2,3,7,8–tetrachlorodibenzo-p-dioxin (TCDD) on the thymus. Toxicology 15: 135–144PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1990

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  • Kiyoshi Imai

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