Autoimmune Hemolytic Anemia, NZB Mice

  • Robert M. Lewis
  • Catherine A. Picut
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Splenomegaly is the most prominent lesion observed in moribund animals. Hepatomegaly and generalized lymphadenopathy are also usually present. All three of these lesions may develop initially at approximately 6 months of age, and increase in magnitude and frequency as the anemia becomes increasingly severe (Creighton et al. 1979). The thymus may or may not be grossly prominent.


Hemolytic disease of NZB mice autoimmune disease of NZB mice 


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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Robert M. Lewis
  • Catherine A. Picut

There are no affiliations available

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