Hemobartonellosis and Eperythrozoonosis

  • Henry J. Baker
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


The phagocytic elements of the spleen, liver, lymph nodes, and other organs appear to be primarily responsible for limiting the multiplication of these parasites. Splenic macrophages are especially important in suppressing the infections, and splenomegaly is often the first and only readily apparent gross pathologic lesion of latent infection. Following experimental injection with E. coccoides (Baker et al. 1971), peak splenic enlargement of 3–4 times normal occurs approximately 7 days after infection but diminishes rapidly during the enusing week and reaches a plateau at 1.5–2 times normal by 21 days. This level of splenomegaly persisted for the remainder of a 42-day observation period. Splenomegaly is also a prominent gross pathologic sign of H. muris infection in rats; however, quantitative data are lacking.


Infected Mouse Deer Mouse Trypanosoma Brucei Plasmodium Berghei Mouse Hepatitis Virus 
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© Springer-Verlag Berlin Heidelberg 1990

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  • Henry J. Baker

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