Calbindin-D9k Localization and Gestational Changes in the Utero-Placental Unit: A Model for Maternal-Fetal Calcium Transports

  • M. Elizabeth Bruns
  • David E. Bruns
Conference paper
Part of the NATO ASI Series book series (volume 48)


The calbindins are a class of E-F hand, high affinity calcium-binding proteins. In a variety of tissues, the synthesis of these proteins is known to be dependent on 1,25dihydroxyvitamin D (1,25 (OH)2D) (Christakos et al., Wasserman et al). Two major forms of calbindins have been isolated and characterized, namely a high molecular weight form of Mr 28,000 (calbindin-D28k) first isolated from chick intestinal epithelium, and a low molecular weight form of Mr 9,000 (calbindin-D9k) first identified in rat intestinal mucosa. These proteins show distinct differences in their distributions, both among species and among tissues. Although the molecular role of these proteins is as yet unclear, ample evidence indicates that calbindins are an excellent marker for epithelia that sustain high rates of transcellular calcium transport (Christakos et al., Wasserman et al.)


Molecular Weight Form High Molecular Weight Form Uterine Muscle Gestational Change Transcellular Calcium Transport 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • M. Elizabeth Bruns
    • 1
  • David E. Bruns
    • 1
  1. 1.Department of PathologyUniversity of Virginia Health Sciences CenterCharlottesvilleUSA

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