Calbindin-D9k Localization and Gestational Changes in the Utero-Placental Unit: A Model for Maternal-Fetal Calcium Transports
The calbindins are a class of E-F hand, high affinity calcium-binding proteins. In a variety of tissues, the synthesis of these proteins is known to be dependent on 1,25dihydroxyvitamin D (1,25 (OH)2D) (Christakos et al., Wasserman et al). Two major forms of calbindins have been isolated and characterized, namely a high molecular weight form of Mr 28,000 (calbindin-D28k) first isolated from chick intestinal epithelium, and a low molecular weight form of Mr 9,000 (calbindin-D9k) first identified in rat intestinal mucosa. These proteins show distinct differences in their distributions, both among species and among tissues. Although the molecular role of these proteins is as yet unclear, ample evidence indicates that calbindins are an excellent marker for epithelia that sustain high rates of transcellular calcium transport (Christakos et al., Wasserman et al.)
KeywordsEstrogen Luminal Tamoxifen Progesterone Oestradiol
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