Free Calcium in Red Blood Cells of Human Hypertensives is Elevated: How Can This be?
Abnormal regulation of calcium transport has been proposed as one mechanism by which increased levels of intracellular free Ca2+ may occur and could be a factor in essential hypertension (Bohr and Webb, 1984). Since vascular smooth muscle cells from human subjects are not readily available for studies of ion transport, circulating blood cells have frequently been used as a model for such measurements in hypertension (Erne et al., 1984a; Lindner et al., 1987; Postnov et al., 1977). While several abnormal Na+ transport pathways have been described in human red blood cells (RBCs) in hypertension (Postnov et al., 1977; Diez et al., 1987), little is known concerning intracellular free Ca2+ in these cells.
KeywordsEssential Hypertension Intracellular Free Calcium Passive Permeability Circulate Blood Cell Human RBCs
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