Regulation of Intracellular Calcium in Cultured Renal Epithelioid (MDCK-) Cells

  • F. Lang
  • M. Paulmichl
  • F. Friedrich
  • J. Pfeilschifter
  • E. Woell
  • H. Weiss
Conference paper
Part of the NATO ASI Series book series (volume 48)


Stimulation of electrolyte transport by hormones involves calcium dependent activation of ion channels in a variety of epithelia. To elucidate the cellular mechanisms and ion channels involved, we have studied the activation of ion channels by epinephrine, bradykinin and ATP in Madin Darby canine kidney (MDCK-) cells [13], a permanent cell line from dog kidney. Chloride secretion in MDCK-cell monolayers has been shown to be stimulated by epinephrine [2,19] and ATP [18].


Extracellular Calcium Pertussis Toxin Permanent Cell Line Half Maximal Concentration Canine Kidney Epithelial Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • F. Lang
    • 1
  • M. Paulmichl
    • 1
  • F. Friedrich
    • 1
  • J. Pfeilschifter
    • 1
    • 2
  • E. Woell
    • 1
  • H. Weiss
    • 1
  1. 1.Department for PhysiologyUniversity of InnsbruckInnsbruckAustria
  2. 2.Ciba Geigy AGBaselSwitzerland

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