Abstract
Inclusion of elemental tellurium in the diet of young rats produces a peripheral neuropathy characterized by a highly synchronous demyelination. This is one of the few such non-immunological models available. Other models may result in an asynchronous patchwork of demyelinating and remyelinating segments (e.g., lead intoxication), or are localized to very discrete regions (e.g., demyelination induced by topical application of lysolecithin or diphtheria toxin). Morphological studies of tellurium intoxication suggest that the initial damage is to the myelinating Schwann cell (Lampert and Garrett, 1971; Hammang et al., 1986) and that vulnerability is proportional to the length of the internodal segment supported by the Schwann cell; the more myelin supported by the Schwann cell, the greater the vulnerability (Bouldin et al., 1988). It is thus uniquely suited for biochemical studies of primary demyelination. Even in the continued presence of tellurium, morphologically observable demyelination diminishes after a few days and, a week after initiation of treatment, the nerve is well launched into a phase of rapid remyelination. We are currently investigating this model with the goal of gaining a better understanding of what metabolic processes are directly affected by tellurium and, assuming there are discrete metabolic alterations, why the resultant pathology is expressed only or preferentially in myelinating Schwann cells.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Benjamins JA, Miller SL, and Morell P (1976) Metabolic relationships between myelin subfractions: Entry of galactolipids and phospholipids. J Neurochem 27: 565–570.
Bouldin TW, Samsa G, Earnhardt T, and Krigman MR (1988) Schwann—cell vulnerability to demyelination is associated with internodal length in tellurium neuropathy. J Neuropathol Exp Neurol 47: 41–47.
Duckett S, Said G, Streletz LG, White RG, and Galle P (1979) Tellurium—induced neuropathy: Correlative physiological, morphological and electron microprobe studies. Neuropathol Appt Neurobiol 5: 265–278.
Folch J, Lees M, and Sloane—Stanley GH (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 479–509.
Hammang JP, Duncan ID, and Gilmore SA, (1986) Degenerative changes in rat intraspinal Schwann cells following tellurium intoxication. Neuropathol Appl Neurobiol 12: 359–370.
Harry GJ, Goodrum JF, Bouldin TW, Wagner—Redo MW, Toews AD, and Morell P (1988) Tellurium—induced neuropathy: Metabolic alterations associated with demyelination and remyelination in rat sciatic nerve. J Neurochem 52: 938–945.
Jackson KF, Hammang JP, Worth SF, Duncan ID (1989) Hypomyelination in the neonatal rat central and peripheral nervous systems following tellurium intoxication. Acta Neuropathol (Berl) 78: 301–309.
Lampert PW and Garrett RS (1971) Mechanism of demyelination in tellurium neuropathy. Electron microscopic observations. Lab Invest 25: 380–388.
Rawlins FA and Smith ME (1971) Myelin synthesis in vitro: A comparative study of central and peripheral nervous tissue. J Neurochem 18: 1861–1870.
Said G, Duckett S, and Sauron B (1981) Proliferation of Schwann cells in tellurium—induced demyelination in young rats. A radioautographic and teased nerve fiber study. Acta Neuropathol (Berl) 53: 173–179.
Takahashi T (1981) Experimental study on segmental demyelination in tellurium neuropathy. Hokkaido J Med Sci 56: 105–131.
Toews AD, Fischer HR, Goodrum JF, and Morell P (1987) Metabolism of phosphate and sulfate groups modifying the Po protein of PNS myelin. J Neurochem 48: 883–887.
Wiggins RC and Morell P (1980) Phosphorylation and fucosylation of myelin proteins in vitro by sciatic nerve from developing rats. J Neurochem 34: 627–634.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Morell, P., Wagner-Recio, M., Toews, A., Harry, J., Bouldin, T.W. (1990). Tellurium-Induced Demyelination. In: Jeserich, G., Althaus, H.H., Waehneldt, T.V. (eds) Cellular and Molecular Biology of Myelination. NATO ASI Series, vol 43. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83968-9_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-83968-9_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83970-2
Online ISBN: 978-3-642-83968-9
eBook Packages: Springer Book Archive