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Some Aspects of Mechanisms of Inflammatory Demyelination

  • Conference paper
Book cover Cellular and Molecular Biology of Myelination

Part of the book series: NATO ASI Series ((ASIH,volume 43))

Abstract

The most extensively studied inflammatory demyelinating diseases are multiple sclerosis (MS) and the animal model, experimental autoimmune encephalomyelitis (RAE). Both are characterized by perivascular inflammation, edema, demyelination and reactive gliosis. In MS the formation of the lesion, which contains T-lymphocytes and macrophages, is generally acknowledged to be related to a cell-mediated immune (CMI) response, and it is known that EAE involves CMI mechanisms requiring T-cell sensitization to a central nervous system antigen. For the past dozen years we have used EAE to explore mechanisms by which such CMI reactions might initiate inflammation, edema and demyelination.

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Author information

Author notes

  1. Ellen Goldmuntz

    Present address: Children’s National Medical Center, 111 Michigan Avenue N.W., Washington, D.C., 20010, USA

Authors and Affiliations

  1. Departments of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA

    William T. Norton & Wendy Cammer

  2. Departments of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA

    Celia F. Brosnan

  3. Departments of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA

    William T. Norton, Celia F. Brosnan, Wendy Cammer & Ellen Goldmuntz

Authors
  1. William T. Norton
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  2. Celia F. Brosnan
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  3. Wendy Cammer
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  4. Ellen Goldmuntz
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Editor information

Editors and Affiliations

  1. FB Biologie/Chemie, Universität Osnabrück, Barbarastraße 11, 4500, Osnabrück, Germany

    Gunnar Jeserich

  2. Max-Planck-Institut für Experimentelle Medizin, Hermann-Rein-Straße 3, 3400, Göttingen, Germany

    Hans H. Althaus  & Thomas V. Waehneldt  & 

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© 1990 Springer-Verlag Berlin Heidelberg

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Norton, W.T., Brosnan, C.F., Cammer, W., Goldmuntz, E. (1990). Some Aspects of Mechanisms of Inflammatory Demyelination. In: Jeserich, G., Althaus, H.H., Waehneldt, T.V. (eds) Cellular and Molecular Biology of Myelination. NATO ASI Series, vol 43. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83968-9_7

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  • DOI: https://doi.org/10.1007/978-3-642-83968-9_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83970-2

  • Online ISBN: 978-3-642-83968-9

  • eBook Packages: Springer Book Archive

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