Protein Kinase C in Neuronal Cell Growth and Differentiation
Protein kinase C (PKC) system is particularly predominant in nervous tissue compared to other tissues as indicated by a high level of the enzyme activity (Kuo et al., 1980) or amount (Girard et al., 1986; Yoshida et al., 1988) and by an abundant occurrence of its substrate proteins (Wrenn et al., 1980). It is likely, therefore, that PKC plays a pivotal role in neuronal function and regulation. In this chapter, I summarized some of our work on immunocytochemical localization of PKC and phosphorylation of endogenous proteins in brain and neuroblastoma cells as they are related to development and differentiation.
KeywordsPurkinje Cell Neurite Outgrowth Myelin Basic Protein Experimental Allergic Encephalomyelitis Dependent Protein Kinase
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