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cAMP-Dependent Protein Kinase: Subunit Diversity and Functional Role in Gene Expression

  • Conference paper
Cellular and Molecular Biology of Myelination

Part of the book series: NATO ASI Series ((ASIH,volume 43))

Abstract

The cAMP-dependent protein kinase (cAMP-PK) exists as an inactive tetramer of two regulatory (R) and two catalytic (C) subunits which are dissociated by cAMP to form an R dimer and two C monomers. The free C subunits are active for substrate phosphorylation. Several subunits have been purified and structurally defined by amino acid sequencing. More recently, heterogenous forms which appear to be products of different genes have been identified by cDNA sequencing. So far a greater number of R subunits than C subunits have been found. The spectrum of mammalian subunits is shown in Table I. From the four different R subunits and two different C subunits, at least 8 different tetrameric holoenzymes can be formed. This minimal number assumes only homodimers of identical R or C subunits. Heterodimers of types I and II R subunits are not found in a holoenzyme complex, however, it has not been demonstrated whether or not α and ß forms can combine to make heterodimers of R-I or R-II.

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Authors and Affiliations

  1. Department of Internal Medicine, Laboratory of Clinical Biochemistry, University of Würzburg, Josef-Schneider-Str. 2, 8700, Würzburg, West Germany

    Matthias Meinecke, Wolfgang Büchler, Lilo Fischer, Suzanne M. Lohmann & Ulrich Walter

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  1. Matthias Meinecke
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  2. Wolfgang Büchler
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  3. Lilo Fischer
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  4. Suzanne M. Lohmann
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  5. Ulrich Walter
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Editors and Affiliations

  1. FB Biologie/Chemie, Universität Osnabrück, Barbarastraße 11, 4500, Osnabrück, Germany

    Gunnar Jeserich

  2. Max-Planck-Institut für Experimentelle Medizin, Hermann-Rein-Straße 3, 3400, Göttingen, Germany

    Hans H. Althaus  & Thomas V. Waehneldt  & 

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© 1990 Springer-Verlag Berlin Heidelberg

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Meinecke, M., Büchler, W., Fischer, L., Lohmann, S.M., Walter, U. (1990). cAMP-Dependent Protein Kinase: Subunit Diversity and Functional Role in Gene Expression. In: Jeserich, G., Althaus, H.H., Waehneldt, T.V. (eds) Cellular and Molecular Biology of Myelination. NATO ASI Series, vol 43. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83968-9_14

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  • DOI: https://doi.org/10.1007/978-3-642-83968-9_14

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