Advertisement

Natural Id-Anti-Id Networks and the Immunological Homunculus

  • I. R. Cohen
Part of the Springer Series in Synergetics book series (SSSYN, volume 46)

Abstract

It is postulated by Jerne and his associates that a network of mutually interacting idiotypes (ids) and anti-idiotypes (anti-ids) is a major factor in regulating the immune response [1]. Analogous to the nervous system wherein an environmental stimulus becomes information as a result of setting into motion self-connected neural networks, the environmental stimulus of the immune system, the antigen, acquires meaning by impinging on self-recognizing id-anti-id networks. Although the id-anti-id hypothesis does not explain or necessitate other demonstrably important immune system factors such as MHC molecules or helper T cells, the notion has fruitfully roused the neural networks of many immunologists.

Keywords

Systemic Lupus Erythematosis Primary Biliary Cirrhosis Thyroid Stimulate Hormone Cell Reactivity Insulin Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    N.K. Jerne: Ann. Immunol. (Inst. Pasteur) 125C, 373 (1974).Google Scholar
  2. 2.
    K. Sege, P.A. Peterson: Proc. Natl. Acad. Sci. USA 75, 2443 (1978).PubMedCrossRefGoogle Scholar
  3. 3.
    Y. Schecter, R. Maron, D. Elias, I.R. Cohen: Science 216, 542 (1982).CrossRefGoogle Scholar
  4. 4.
    Y. Schecter, D. Elias, R. Maron, I.R. Cohen: J. Biol. Chem. 259, 6411 (1984).Google Scholar
  5. 5.
    D. Elias, R. Maron, I.R. Cohen, Y. Shechter: J. Biol. Chem. 259, 6416 (1984).PubMedGoogle Scholar
  6. 6.
    I.R. Cohen, D. Elias, R. Maron, Y. Shechter: In Idiotypy in Biology and Medicine. ed. by H. Kohler, J. Urbain, P.A. Cazenave 20, 385 (Academic Press, New York, 1984).Google Scholar
  7. 7.
    Y. Shechter, D. Elias, R. Bruck, R. Maron, I.R. Cohen: In Anti-idiotvpes. Receptors and Molecular Mimicry. ed. by D. S. Linthicum, N.R. Farid, 73 (Springer-Verlag, 1988).Google Scholar
  8. 8.
    R.W. Neville, B.J. Weir, N.R. Lazarus:Diabetes 22, 851 (1973).PubMedGoogle Scholar
  9. 9.
    I.R. Cohen, D. Elias, M. Rapopport, Y. Shechter: Methods in Enzymology (in press 1989).Google Scholar
  10. 10.
    D. Elias, M. Rapopport, I.R. Cohen, Y. Shechter: J. Clin. Invest. 81, 1979 (1988).PubMedCrossRefGoogle Scholar
  11. 11.
    D. Elias et al in preparation.Google Scholar
  12. 12.
    D. Elias, I.R. Cohen, Y. Shechter, Z. Spirer, A. Golander: Diabetes 36, 348 (1987).PubMedCrossRefGoogle Scholar
  13. 13.
    N.H. Wassermann et al: Proc. Natl. Acad. Sci. USA 79, 4810 (1982).PubMedCrossRefGoogle Scholar
  14. 14.
    G.N. Beall, B. Rapoport, I.J. Chopra, S.R. Kruger: J. Clin. Invest. 75, 1435 (1985).PubMedCrossRefGoogle Scholar
  15. 15.
    S. Mendlovic, S. Brocke, Y. Shoenfeld, M. Ben-Bassat, A. Meshorer, R. Bakimer, E. Mozes: Proc. Natl. Acad. Sci. USA. 85, 2260 (1988).PubMedCrossRefGoogle Scholar
  16. 16.
    M. Lugate et al: J. Clin. Endocrinol. Metab. (in press).Google Scholar
  17. 17.
    S.J. Yeaman et al: Lancet I, 1067 (1988).CrossRefGoogle Scholar
  18. 18.
    M. Guegen et al: J. Exp. Med. 168, 801 (1988).CrossRefGoogle Scholar
  19. 19.
    J.H. Shero et al: Science 231, 737 (1987).CrossRefGoogle Scholar
  20. 20.
    D. Young, R. Lathigra, R. Hendrix, D. Sweetser, R.A. Young: Proc. Natl. Acad. Sci. USA 85, 4267 (1988).PubMedCrossRefGoogle Scholar
  21. 21.
    W. van Eden, J. Thole, R. Van Der Zee, A. Noordzij, J.D.A. van Embden, E.J. Hensen, I.R. Cohen: Nature 331, 171 (1988).PubMedCrossRefGoogle Scholar
  22. 22.
    P.C.M. Res, C.G. Schaar, F.C. Breedveld, W. van Eden, J.D.A. van Embden, I.R. Cohen, R.R.P. de Vries: The Lancet II, 478 (1988).CrossRefGoogle Scholar
  23. 23.
    I.R. Cohen, H. Atlan: J. Autoimmunity, in press.Google Scholar
  24. 24.
    H. von Boehmer, H.S. Teh, P. Kisielow: Immunology Today 10, 57 (1989).CrossRefGoogle Scholar
  25. 25.
    P.J. Bjorkman et al: Nature 329, 506 (1987).PubMedCrossRefGoogle Scholar
  26. 26.
    I.R. Cohen: Immunological Rev. 94, 5 (1986).CrossRefGoogle Scholar
  27. 27.
    O. Lider, E. Beraud, T. Reshef, I.R. Cohen: Science 239, 181 (1988).PubMedCrossRefGoogle Scholar
  28. 28.
    I.R. Cohen, H.L. Weiner: Immunology Today 9. 322 (1988).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin, Heidelberg 1989

Authors and Affiliations

  • I. R. Cohen
    • 1
  1. 1.Department of Cell BiologyThe Weizmann Institute of ScienceRehovotIsrael

Personalised recommendations