Natural Id-Anti-Id Networks and the Immunological Homunculus

  • I. R. Cohen
Part of the Springer Series in Synergetics book series (SSSYN, volume 46)


It is postulated by Jerne and his associates that a network of mutually interacting idiotypes (ids) and anti-idiotypes (anti-ids) is a major factor in regulating the immune response [1]. Analogous to the nervous system wherein an environmental stimulus becomes information as a result of setting into motion self-connected neural networks, the environmental stimulus of the immune system, the antigen, acquires meaning by impinging on self-recognizing id-anti-id networks. Although the id-anti-id hypothesis does not explain or necessitate other demonstrably important immune system factors such as MHC molecules or helper T cells, the notion has fruitfully roused the neural networks of many immunologists.


Systemic Lupus Erythematosis Primary Biliary Cirrhosis Thyroid Stimulate Hormone Cell Reactivity Insulin Molecule 
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Copyright information

© Springer-Verlag Berlin, Heidelberg 1989

Authors and Affiliations

  • I. R. Cohen
    • 1
  1. 1.Department of Cell BiologyThe Weizmann Institute of ScienceRehovotIsrael

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