Optimizing the Immune Control of Parasitic Invasion
The aim of this work is to identify the crucial tasks of the immune system in controlling parasitic invasion and to examine plausible molecular mechanisms by which these tasks may be effectuated. To this end the Sleeping Sickness, and its causative agent Trypanosoma brucei are discussed in terms of a general optimization problem, thus illustrating the major difficulties in controlling this disease. Subsequently an automata model is presented, of B-cell population dynamics under the constraints of a trypanosome-like pathogen. The efficacy of different mechanisms for optimizing the immune response are tested.
KeywordsMajority Rule Genomic Mutation Immune Control Parasitic Invasion Antibody Repertoire
Unable to display preview. Download preview PDF.
- 1.I. Roitt: Essential Immunology, Blackwell Scientific Publications (1988).Google Scholar
- 3.K.J. Vickerman: Cell Sci. 5, 163 (1969).Google Scholar
- 7.Capbern: et al. Parasitol. 42, 6 (1982).Google Scholar
- 9.K. Vickerman & J.D. Barry: In The Immunology of Parasite Infection ed. by S. Cohen & K.S. Warren, Blackwell Scientific Publications, Oxford (1982).Google Scholar
- 11.K.J. Vickerman: In Parasites in the Immunized Host: Mechanisms of Survival, Ciba Foundations Symposium (Elsevier), pp. 53-80 (1974).Google Scholar
- 16.D. Abiri, L.H.T. Van der Ploeg & Z. Agur: (to appear).Google Scholar