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Optimizing the Immune Control of Parasitic Invasion

Conference paper
Part of the Springer Series in Synergetics book series (SSSYN, volume 46)

Abstract

The aim of this work is to identify the crucial tasks of the immune system in controlling parasitic invasion and to examine plausible molecular mechanisms by which these tasks may be effectuated. To this end the Sleeping Sickness, and its causative agent Trypanosoma brucei are discussed in terms of a general optimization problem, thus illustrating the major difficulties in controlling this disease. Subsequently an automata model is presented, of B-cell population dynamics under the constraints of a trypanosome-like pathogen. The efficacy of different mechanisms for optimizing the immune response are tested.

Keywords

Majority Rule Genomic Mutation Immune Control Parasitic Invasion Antibody Repertoire 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin, Heidelberg 1989

Authors and Affiliations

  • Z. Agur
    • 1
  1. 1.Dept. of Applied Math. & Computer ScienceThe Weizmann Institute of ScienceRehovotIsrael

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