Skip to main content

Energy Metabolism in Brain Injury

  • Conference paper
Brain Failure

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 9))

Abstract

Brain failure is associated with extensive physiological changes, involving circulation, respiration, metabolism, endocrine and immunological systems. These changes have been well studied in patients with non cranial trauma and less extensively in patients with head trauma. In the latter, these responses can be so severe as to threaten the outcome. Most of the studies on energy metabolism in patients suffering from acute brain failure have been carried out in head-injured patients; very few have been published concerning other kinds of brain failure. In this paper, some of the basic information regarding the changes in energy metabolism in patients suffering from head injury will be reviewed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Frayn K (1986) Hormonal control of metabolism in trauma and sepsis. Clin Endocrinol 24:577–599

    Article  CAS  Google Scholar 

  2. Chiolero RL, Lemarchand TH, Schutz Y, et al (1988) Plasma pituitary hormone levels in severe trauma with or without head injury. J Trauma 28:1368–1374

    Article  PubMed  CAS  Google Scholar 

  3. Chiolero R, Schutz Y, Lemarchand TH, et al (1989) Hormonal and metabolic changes following severe head injury or non cranial injury. JPEN 13:5–12

    Article  CAS  Google Scholar 

  4. Gelfand RA, de Fronzo RA, Goldberg R (1983) Metabolic alterations associated with major injury or infection. In: Kleinberger G, Deutsch E (eds) New aspects of clinical nutrition. Karger, Basel, pp 247–270

    Google Scholar 

  5. Pomposelli JJ, Flores EA, Bistrian B (1988) Role of biochemical mediators in clinical nutrition and surgical metabolism. JPEN 12:212–218

    Article  CAS  Google Scholar 

  6. Elwyn DH (1987) Protein metabolism and requirements in the critically ill patient. Crit Care Clin 3:57–69

    PubMed  CAS  Google Scholar 

  7. Jequier E, Acheson K, Schutz Y (1987) Assessment of energy expenditure and fuel utilization in man. Ann Rev Nutr 7:187–208

    Article  CAS  Google Scholar 

  8. Damask MC, Schwarz Y, Weissman C (1987) Energy measurements and requirements of critically ill patients. Crit Care Clin 3:71–96

    PubMed  CAS  Google Scholar 

  9. Haider W, Lackner F, Schlick W, et al (1975) Metabolic changes in the course of severe acute brain damage. Eur J Intensive Care Med 1:19–26

    Article  Google Scholar 

  10. Clifton GL, Robertson CS, Grossman RG, et al (1984) The metabolic response to severe head injury. J Neurosurg 60:687–696

    Article  PubMed  CAS  Google Scholar 

  11. Dempsey DT, Guenter P, Mullen JL, et al (1985) Energy expenditure in acute trauma to the head with and without barbiturate therapy. Surg Gynecol Obstet 160:128–134

    PubMed  CAS  Google Scholar 

  12. Robertson CS, Clifton GL, Goodman JF (1985) Steroid administration and nitrogen excre tion in the head-injured patient. J Neurosurg 63:714–718

    Article  PubMed  CAS  Google Scholar 

  13. Young B, Ott L, Norton J, et al (1985) Metabolic and nutritional sequelae in the non-steroid treated head injury patient. Neurosurgery 17:784–790

    Article  PubMed  CAS  Google Scholar 

  14. Clifton GL, Robertson CS, Choi SC (1986) Assessment of nutritional requirements of head-injured patients. J Neurosurg 64:895–901

    Article  PubMed  CAS  Google Scholar 

  15. Fruin AH, Taylon C, Pettis MS (1986) Caloric requirements in patients with severe head injuries. Surg Neurol 25:25–28

    Article  PubMed  CAS  Google Scholar 

  16. Ott L, Young B, McClain C (1987) The metabolic response to brain injury. JPEN 11:488–493

    Article  CAS  Google Scholar 

  17. Chiolero RL, Breitenstein E, Schutz Y, et al (1989) Effects of propranolol on resting metabolic rate after severe head injury. Crit Care Med (in press)

    Google Scholar 

  18. Clifton GL, Robertson CS, Kyper K, et al (1983) Cardiovascular response to severe head injury. J Neurosurg 59:447–454

    Article  PubMed  CAS  Google Scholar 

  19. Sanjak M, Paulson D, Sufit R, et al (1987) Physiologic and metabolic response to progressive and prolonged exercise in amyotrophic lateral sclerosis. Neurology 37:1217–1220

    PubMed  CAS  Google Scholar 

  20. Hemmer M (1987) Non-neurological management of head injury. In: Vincent JL (ed) Update in intensive care and emergency medicine, vol 3. Springer, Berlin Heidelberg New York Tokyo, pp 402–406

    Google Scholar 

  21. Rapp RP, Young B, Twyman D, et al (1983) The favorable effects of early parenteral feeding on survival in head-injured patients. J Neurosurg 58:906–912

    Article  PubMed  CAS  Google Scholar 

  22. Sjöström L, Schutz Y, Gudinchet F, et al (1983) Epinephrine sensitivity with respect to metabolic rate and other variables in women. Am J Physiol 245(8):E431–E442

    PubMed  Google Scholar 

  23. Swinaher DL, Phang PT, Jones RL, et al (1988) Effect of routine administration of analgesia on energy expenditure in critically ill patients. Chest 92:4–10

    Article  Google Scholar 

  24. MacIntyre PE, Pavlin EG, Dwersteg JF (1987) Effect of meperidine on oxygen consumption, carbon dioxide production and respiratory gas exchange in postanesthesia shivering. Anesth Analg 66:751–755

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Chiolero, R.L., de Tribolet, N., Schutz, Y. (1989). Energy Metabolism in Brain Injury. In: Bihari, D., Holaday, J.W. (eds) Brain Failure. Update in Intensive Care and Emergency Medicine, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83929-0_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-83929-0_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51655-2

  • Online ISBN: 978-3-642-83929-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics