Control of Volume and pH
Jacobs and Stewart (1947) presented a detailed description of the acid-base and volume behaviour of human red cells, based on the Donnan equilibrium theory. The red cell was considered to be impermeable to cations and large intracellular anions such as haemoglobin, but permeable to small anions, water and carbon dioxide. In addition, the hydration/dehydration reactions of carbon dioxide were known to be catalysed by carbonic anhydrase within the cell.
KeywordsPermeability Hydration Dehydration Cyanide Guanine
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