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Indoor Air Quality pp 138–146Cite as

Urinary Mutagenicity, Hydroxyphenanthrene, and Thioether Excretion After Exposure to Environmental Tobacco Smoke

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Summary

In two controlled studies 10 non-smokers each were exposed for 8 h to environmental tobacco smoke (ETS) equivalent to 10ppm CO (Experiment 1) and 25ppm CO (Experiment 2). During the control and the exposure period the room air was monitored for CO, NO, NO2, nicotine and formaldehyde. Biomonitoring included determination of carboxyhemoglobin (COHb), cotinine in serum and urine, and urinary excretion of five different monohydroxyphenanthrenes (OH-PHE), thioethers and mutagenic activity (as detected by the Salmonella typhimurium TA 98/microsome assay). The observed increases in COHb indicate that ETS exposure in Experiment 1 was substantially higher than in a real-life situation, whereas that in Experiment 2 bore no relation to common passive smoking. This is mainly due to the fact that high ETS exposure in a real-life situation is usually much shorter than 8 h per day. Urinary excretion of OH-PHE and mutagenicity was not significantly increased after both experimental ETS exposures. In contrast to this, excretion of thioethers was elevated after ETS exposure in Experiment 1 (P = 0.07) and Experiment 2 (P < 0.001). Our results suggest that non-smokers in real-life situations take up very low doses of ETS constituents, which in case of potentially genotoxic substances are likely to be detoxified.

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Authors
  1. G. Scherer
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  2. K. Westphal
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  3. F. Adlkofer
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Editor information

Editors and Affiliations

  1. Department of Public Health, School of Medicine, Tokai University, Bohseidai, Isehara-shi, Kanagawa, 259-11, Japan

    Hitoshi Kasuga

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© 1990 Springer-Verlag Berlin Heidelberg

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Scherer, G., Westphal, K., Adlkofer, F. (1990). Urinary Mutagenicity, Hydroxyphenanthrene, and Thioether Excretion After Exposure to Environmental Tobacco Smoke. In: Kasuga, H. (eds) Indoor Air Quality. International Archives of Occupational and Environmental Health Supplement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83904-7_16

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  • DOI: https://doi.org/10.1007/978-3-642-83904-7_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51580-7

  • Online ISBN: 978-3-642-83904-7

  • eBook Packages: Springer Book Archive

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