Principles and Present Role of Extracorporal Elimination of CO2 in the Therapy of Respiratory Failure
Adult respiratory distress syndrome (ARDS), defined by Ashbaugh et al.  as an acute arterial hypoxia, has a high mortality. In the NIH study  in the early 1970s mortality was 80%–90%, and in the most recent European study by Artigas , for patients in Morel’s stages III–IV , the percentage is 70%. In this study we discuss ARDS patients in stages III and IV. Death, however, is not only caused by ARDS but also by the basic disease. The lungs of patients with severe progressive ARDS, i.e., with ARDS developing continuously for days or even weeks, show disturbances of ventilation and perfusion that are not only regionally distributed. They range from ventilated nonperfused to perfused nonventilated alveolar regions without fixed boundaries.
KeywordsAdult Respiratory Distress Syndrome Extravascular Lung Water Membrane Lung Present Role Venovenous Bypass
Unable to display preview. Download preview PDF.
- 3.European ARDS Collaborative Working Group (1988) Adult respiratory distress syndrome (ARDS). Clinical predictors, pronostic factors and outcome. Intensive Care Med 14 [Suppl 1]:300Google Scholar
- 4.Gattinoni L, Agostoni A, Pesenti A, Pelizzola A, Rossi G, Langer M, Vesconti S, Uziel L, Fox U, Longoni F, Kolobow T (1980) Treatment of acute respiratory failure with low frequency positive-pressure ventilation and extracorporeal removal of CO2. Lancet 11:29Google Scholar
- 5.Jardin F (1979) Pulmonary hemodynamics and gas exchange during venoarterial bypass with membrane-lung oxygenation. In: Unger, Regnier B, Gastine H, Lemaire F (eds) Assisted circulation. Springer, Berlin Heidelberg New YorkGoogle Scholar
- 6.Kolobow T, Gattinoni L, Tomlinson TA, Pierce JE (1977) Laboratory report. Control of breathing using an extracorporeal membrane lung. Anaesthesiology 46:138–141Google Scholar
- 8.National Heart Lung and Blood Institute. Division of Lung Diseases (1970) Extracorporeal support for respiratory insufficiency: a collaborative study. Nahonal Institute of Health, BethesdaGoogle Scholar