Angiotensin I Forming Angiotensinogenases (Renin-Like Enzymes) in the Heart — Evidence for Their Location in the Coronaries
Previous investigations demonstrated the presence of renin or renin-like enzymes (angiotensin I forming angiotensinogenases = AIFAs) in the heart. Other studies indicated the existence of similar enzymes in extracardiac (extrarenal) vascular walls (for a comprehensive survey see ). — The question thus arises whether the AIFAs demonstrated in the heart are contained in the coronaries. The present study was designed to identify and biochemically characterize AIFAs in cardiac tissues of the rat and to compare them with the enzymes in extracardiac (extrarenal) vascular walls. For this purpose, Fast Protein Liquid Chromatography (FPLC) of cardiac AIFAs and extracardiac (extrarenal) vascular wall AIFAs was applied and the pH optima of the separated enzymes measured.
Key wordsRenin-angiotensin system Heart Fast protein liquid chromatography
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