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Angiotensin I Forming Angiotensinogenases (Renin-Like Enzymes) in the Heart — Evidence for Their Location in the Coronaries

  • H. Dahlheim
  • M. Thurnreiter
  • M. Plaschke
  • W. Reiter
  • I. Durasin
  • J. Rosenthal
Conference paper

Abstract

Previous investigations demonstrated the presence of renin or renin-like enzymes (angiotensin I forming angiotensinogenases = AIFAs) in the heart. Other studies indicated the existence of similar enzymes in extracardiac (extrarenal) vascular walls (for a comprehensive survey see [1]). — The question thus arises whether the AIFAs demonstrated in the heart are contained in the coronaries. The present study was designed to identify and biochemically characterize AIFAs in cardiac tissues of the rat and to compare them with the enzymes in extracardiac (extrarenal) vascular walls. For this purpose, Fast Protein Liquid Chromatography (FPLC) of cardiac AIFAs and extracardiac (extrarenal) vascular wall AIFAs was applied and the pH optima of the separated enzymes measured.

Key words

Renin-angiotensin system Heart Fast protein liquid chromatography 

References

  1. 1.
    Dahlheim H, Jacob ICM, Pschorr J, Rosenthal J (1983) The renin-angiotensin system in the extrarenal vascular walls: an approach to studies in humans. In: Fotherby K, Pal SB (eds) Hormones in normal and abnormal tissues, vol III. Walter de Gruyter, Berlin, pp 251–284Google Scholar
  2. 2.
    Kim SH, Lloyd MC, Sessler FM, Feng J, Malvin RL (1988) Functional differences of six forms of renin in rats. Am J Physiol 254: F432 — F439PubMedGoogle Scholar
  3. 3.
    Rosenthal J, Pfeifle B, Michailov ML, Pschorr J, Jacob ICM, Dahlheim H (1984) Investigations of components of the renin-angiotensin system in rat vascular tissue. Hypertension 6: 383–390PubMedGoogle Scholar
  4. 4.
    Rosenthal J, v Lutterotti N, Thurnreiter M, Gomba S, Rothemund J, Reiter W, Kazda S, Garthoff B, Jacob I, Dahlheim H (1987) Suppression of renin-angiotensin system in the heart of spontaneously hypertensive rats. J Hypertension 5 [Suppl 2]: 23–31Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • H. Dahlheim
    • 1
  • M. Thurnreiter
    • 1
  • M. Plaschke
    • 1
  • W. Reiter
    • 1
  • I. Durasin
    • 1
  • J. Rosenthal
    • 1
  1. 1.Department of PhysiologyUniversity of Munich and Ulm University Medical CenterGermany

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