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Efficacy of Alpha-Methyldopa in Ventricular Arrhythmias by Decrease of Sympathetic Activity

  • P. Brugger
Conference paper

Abstract

Identifying patients at increased risk of sudden death continues to be a key problem in contemporary cardiology. It has been recognized that certain types of ventricular premature beats (specifically, repetitive forms or runs of ventricular tachycardia) enhances the risk for sudden cardiac death [4, 27, 29] and that patients with coronary artery disease (CAD) and symptomatic ventricular tachycardia or ventricular fibrillation in their history, are especially prone to sudden death.

Key words

Alpha-methyldopa Ventricular arrhythmias Sympathetic activity 

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References

  1. 1.
    A multicentre international study (1975) Improvement of prognosis of myocardial infarction by long-term beta-adrenoceptor blockade using practolol. Br J Med 3: 735–740CrossRefGoogle Scholar
  2. 2.
    Ahlmark G, Saetre H (1976) Long-term treatment with beta-blockers after myocardial infarction. Eur J Clin Pharmacol 10: 77–83PubMedCrossRefGoogle Scholar
  3. 3.
    Bethge KP, Klein H. Lichtlen PR (1970) Koronare Herzerkrankung, Rhythmusstörungen and plötzlicher Herztod. Internist Welt 2: 107–117Google Scholar
  4. 4.
    Bigger JT, Weld FM, Rolnitzky LM (1981) Prevalence, characteristics and significance of ventricular tachycardia (three or more complexes) detected with ambulatory monitoring in the late hospital phase of acute myocardial infarction. Am J Cardiol 48: 815–823PubMedCrossRefGoogle Scholar
  5. 5.
    Cox WV, Robertson HF (1936) The effect of stellate ganglionectomy on the cardiac function of intact dogs and its effect on the extent of myocardial infarction and on cardiac function following coronary artery occlusion. Am Heart J 12: 285–300CrossRefGoogle Scholar
  6. 6.
    Erlij D, Mendez R (1964) The modification of digitalis intoxication by excluding adrenergic influences on the heart. J Pharmacol Exp Ther 144: 97–193PubMedGoogle Scholar
  7. 7.
    Garrey WE (1908) Some effects of cardiac nerves upon ventricular fibrillation. Am J Physiol 21: 282–300Google Scholar
  8. 8.
    Grossmann MA (1976) Cardiac arrhythmias in acute CNS disease-successfull management with stellate ganglion block. Arch Intern Med 136: 203–207CrossRefGoogle Scholar
  9. 9.
    Han J, Garcia de Jalon P, Moe G (1964) Adrenergic effects on cardiac vulnerability. Circ Res 14: 516PubMedGoogle Scholar
  10. 10.
    Harris AS, Estandia A, Tillotson RF (1951) Ventricular ectopic rhythms and ventricular fibrillation following cardiac sympathectomie and coronary occlusion. Am J Physiol 165: 505–512PubMedGoogle Scholar
  11. 11.
    Hoff HE, Nahum LH (1934) The role of adrenaline in the production of ventricular rhythms and their supression by acetyl-betaShort Communications methyl-choline chloride. J Pharmacol Exp Ther 52: 235–245Google Scholar
  12. 12.
    Hoff HE, Nahum LH (1935) The nature of ventricular fibrillation following electric schock and its prevention by acetyl-betamethyl-choline chloride. Am J Physiol 110: 680Google Scholar
  13. 13.
    Hunt R (1899) Direct and reflex acceleration of the mammalian heart with some observations on the relations of the inhibitory and accelerator nerves. Am J Physiol 2: 395–470Google Scholar
  14. 14.
    Kelliher G, Roberts J (1974) A study of the antiarrhythmic action of certain beta-blocking agents. Am Heart J 87: 458–467PubMedCrossRefGoogle Scholar
  15. 15.
    Khan MI, Hamilton JT, Manning GW (1972) Protective effects of beta-adrenoceptor blockade in experimental coronary occlusion in conscious dogs. Am J Cardiol 30: 832–837PubMedCrossRefGoogle Scholar
  16. 16.
    Kliks BR, Burgess M, Abildskov JA (1975) Influence of sympathetic tone on ventricular fibrillation threshold during experimental coronary occlusion. Am J Cardiol 36: 45–49PubMedCrossRefGoogle Scholar
  17. 17.
    Korteweg GCJ, Boeles TF, Tencate J (1975) Influence of stimulation of some subcortical areas on electrocardiogram. J Neurophysiol 20: 100Google Scholar
  18. 18.
    LeRoy GV, Snider SS (1941) The sudden death of patients with few symptoms of heart disease. JAMA 117: 2019–2024CrossRefGoogle Scholar
  19. 19.
    Levy AG (1913) The exciting causes of ventricular fibrillation in animals under chloroform anesthesia. Heart 4: 319–378Google Scholar
  20. 20.
    Lown B, Wolf M (1971) Approaches to sudden death from coronary heart disease. Circulation 44: 130PubMedGoogle Scholar
  21. 21.
    Lown B, Verrier RL, Rabinowitz SH (1977) Neural and psychologie mechanisms and the problem of sudden cardiac death. Am J Cardiol 39: 890–902PubMedCrossRefGoogle Scholar
  22. 22.
    McEachern G, Manning GW, Hall GE (1940) Sudden occlusion of coronary arteries following removal of cardiosensory pathways. Arch Intern Med 65: 661–670CrossRefGoogle Scholar
  23. 23.
    Muscholl E, Rahn KH (1966) Nachweis von alpha-Methylnoradrenalin im Ham von Hypertonikern während einer Behandlung mit alpha-Methyldopa. Klin Wochenschr 44: 1412–1413PubMedCrossRefGoogle Scholar
  24. 24.
    Otto HL (1927) Über die Beziehungen der Accelerantes zu den Folgen der Unterbindung von Coronargefäßen. Arch Ges Physiol 217: 528–530CrossRefGoogle Scholar
  25. 25.
    Pearle DL, Gillis RA (1974) Effect of digitalis on response of the ventricular pacemaker to sympathetic neural stimulation and to isoproterenol. Am J Cardiol 34: 704–710PubMedCrossRefGoogle Scholar
  26. 26.
    Philippu A, Schuemann HJ (1965) Effect of alpha-methyldopa, alpha-methyldopamine, and alphamethylnorepinephrine on the norepinephrine content of the isolated heart. Life Sci 4: 2039–2046PubMedCrossRefGoogle Scholar
  27. 27.
    Podrid JP (1985) Treatment of ventricular arrhythmia. Applications and limitations of noninvasive vs invasive approach. Chest 88: 121–128PubMedCrossRefGoogle Scholar
  28. 28.
    Rabinowitz SH, Verrier RL, Lown B (1976) Muscarinic effects of vagosympathetic trunk stimulation on the repetive extrasystole (RE) threshold. Circulation 53: 622–627PubMedGoogle Scholar
  29. 29.
    Ruberman W, Weinblatt E, Goldberg JD, Frank CW, Shapiro S (1977): Ventricular premature beats and mortality after myocardial infarction. N Engl J Med 279: 750–757CrossRefGoogle Scholar
  30. 30.
    Ruberman W, Weinblatt E, Goldberg J, Frank CW (1980): Sudden death of myocardial infarction: runs of ventricular premature beats and R-on-T as high risk factors (abstr). Am J Cardiol 45: 444CrossRefGoogle Scholar
  31. 31.
    Shumaker HB, Riberl A, Boone RD, et al. (1954) Ventricular fibrillation in the hypothermic state. IV. The role of extrinsic cardiac innervation. Ann Surg 143: 223–229Google Scholar
  32. 32.
    Verrier RL, Calvert A, Lown B (1975) Effect of posterior hypothalamic stimulation on the ventricular fibrillation threshold. Am J Physiol 228: 923PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • P. Brugger
    • 1
  1. 1.Pensionsversicherungsanstalt der ArbeiterLandesstelle SalzburgAustria

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