Abstract
Cardiomegaly by hypertrophy of the heart in acromegalic patients — prevalence 85% in our patients with acromegaly [1] — is often complicated by complex arrhythmias and gradual cardiac-insufficiency [1, 3, 8]. The aim of the study was to evaluate the extend of heart size reduction in acromegalic patients under longterm-treatment with the long-acting somatostatin-analgoue SMS 201–995 (Sandostatin®, Sandoz) [2, 5, 7]. All patients had been treated before SMS 201–995 therapy by neurosurgery and/or radiation and medical treatment with bromocriptine (Pravidel®), so that hypersomatotropism before SMS 201–995 therapy was only moderate (s. Table la).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Althoff P-H (1978) Die Akromegalie — Untersuchungen zur Pathophysiologie der Wachstumshormonsekretion und zur Pharmakotherapie mit Somatostatin und Bromocriptin. Habilitationsschrift, Frankfurt
Ch’ng LJC, Sandler LM, Kraenzlin ME, Bur-rin JM, Joplin GF, Bloom SR (1985) Long term treatment of acromegaly with a long acting analogue of somatostatin. Br Med J 290: 284–285
Happ J, Gerspach A, Maul FD, Standke R, Böttger B, Althoff P-H, Schöffling K, Hör G (1984) Myocardial Scintigraphy (MS) in Acromegalics. In: Schmidt HAE, Adam WE (eds) Nuklearmedizin. Schattauer, Stuttgart New York, pp 156–157
Hopf R, Böhmer D, Kaltenbach M (1977) Röntgenologische Herzvolumenbestimmung. Beschreibung einer neueren Methode mit Durchführung im Sitzen. Fortschr Röntgenstr 127: 167–169
Lamberts SWJ, Uitterlinden P, Verschoor L, van Dongen KJ, Del Pozo E (1985) Long-Term treatment of acromegaly with the somatostatin analogue SMS 201–995. N Engl J Med 313: 1576–1580
Musshoff K, Raindell H, Gebhardt W, König K, Roskam H (1967) Die Methode der röntgenologischen Volumenbestimmung des Herzens. Radiologe 7: 161–164
Schmidt K, Rübesam D, Althoff P-H, Jungmann E, Harris AG, Schöffling K (1989) Organ size reduction in acromegalic patients treated with the somatostatin analog SMS 201995. Acta Endocrin (Kbh) 120: Supp11: 80
Smallridge RC, Rajfer S, Davia J, Schaaf M (1979) Acromegaly and the heart. An echocardiographic study. Am J Med 66: 22–27
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Althoff, PH., Schmidt, K., Rübesam, D., Harris, A.G., Jungmann, E., Schöffling, K. (1989). Heart Size Reduction in Acromegalic Patientes Treated with the Long-Acting Somatostatin-Analogue SMS 201–995 (Somatostatin®). In: Kaufmann, W., Wambach, G. (eds) Endocrinology of the Heart. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83858-3_56
Download citation
DOI: https://doi.org/10.1007/978-3-642-83858-3_56
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-51409-1
Online ISBN: 978-3-642-83858-3
eBook Packages: Springer Book Archive