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Heart Size Reduction in Acromegalic Patientes Treated with the Long-Acting Somatostatin-Analogue SMS 201–995 (Somatostatin®)

  • P.-H. Althoff
  • K. Schmidt
  • D. Rübesam
  • A. G. Harris
  • E. Jungmann
  • K. Schöffling
Conference paper

Abstract

Cardiomegaly by hypertrophy of the heart in acromegalic patients — prevalence 85% in our patients with acromegaly [1] — is often complicated by complex arrhythmias and gradual cardiac-insufficiency [1, 3, 8]. The aim of the study was to evaluate the extend of heart size reduction in acromegalic patients under longterm-treatment with the long-acting somatostatin-analgoue SMS 201–995 (Sandostatin®, Sandoz) [2, 5, 7]. All patients had been treated before SMS 201–995 therapy by neurosurgery and/or radiation and medical treatment with bromocriptine (Pravidel®), so that hypersomatotropism before SMS 201–995 therapy was only moderate (s. Table la).

Key words

Acromegaly Pharmacotherapy Somatostatin Heart size reduction 

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • P.-H. Althoff
    • 1
  • K. Schmidt
    • 1
  • D. Rübesam
    • 1
  • A. G. Harris
    • 1
  • E. Jungmann
    • 1
  • K. Schöffling
    • 1
  1. 1.Department of Endocrinology, Center of Internal MedicineJ. W. Goethe-UniversityFrankfurtGermany

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