Abstract
During pregnancy various humoral and functional mechanisms were recognized, that regulate the water and electrolyte household. In preeclampsia, increased water-sodium retention results from a variety of pathophysiological changes in the endocrinological system. There are also organ-specific changes, such as renal clearance reduction up to 30% in comparison to normal pregnancy. For many years, physiologists expected to find additional cardial mechanisms that influence homeostasis. In 1981, de Bold [3] identified ANP a new humoral factor that leads to increased water and sodium excretion. The influence of ANP in preeclampsia has been the subject of controversial discussion.
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Cowan BD, Martin JN, Tucker JM, Martin RW, Morrison JC, Kikokawa T, Mukhergèe AB (1988) High plasma concentrations of human atrial natriuretic polypeptide in women with pregnancy — induced hypertension. Proceedings ISSHP, Montreal, p 45
Cusson JR, Gutkowska J, Rey E, Mickon N, Boucher M, Larochelle P (1985) Plasma concentration of atrial natriuretic factor in normal pregnancy. N Engl J Med 313: 1230–1231
De Bold AJ, Borenstein HB, Veress AT, Sonnenberg H (1981) A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci 28: 89–94
Eastmann J, Bell ST, Dieckmann WJ (1952) Definition and classification of toxaemias brought up to date. American Committee on Maternal Welfare, Chicago
Niesert S, Gunter HH, Kaulhausen H (1987) Atrial natriuretic peptidide during pregnancy. Lancet 11: 404–405
Rutherford AJ, Anderson JV, Elder MG, Bloom SR (1987) Release of atrial natriuretic peptide during pregnancy and immediate puerperium. Lancet 1: 928–929
Steegers EA, Tan AC, Coumans HJ, Benraad TJ, Groeneveld EA, Jongsma HW, Hein PR (1988) Atrial natriureticpeptide, aldosterone, plasma renin activity and diuresis in puerperium. Proceedings JSSHP, Montreal, p 46
Thomsen JK, Storen TL, Thambsborg G, De Nully M, Bodker B, Skouby S (1987) Atrialnatriuretic peptide concentrations in preeclampsia. Br Med J 294: 1508–1510
Weidmann P, Hasler L, Gnädinger MP, Lang RE, Uehlinger DE, Shaw S, Rascher W, Renbi FC (1986) Blood levels and renal effects of atrial natriuretic peptide in normal man. J Clin Invest 77: 734–742
Weil J, Bidlingmaier F, Döhlemann C, Kühnle V, Strom T, Lang RE (1986) Comparison of plasma atrial natriuretic peptide levels in healthy children from birth to adolescence and in children with cardiac diseases. Pediatr Res 20: 1328–1331
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© 1989 Springer-Verlag Berlin Heidelberg
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Casper, F., Seufert, R., Lang, R.E. (1989). Artrial Natriuretic Peptide Concentrations in Preeclampsia. In: Kaufmann, W., Wambach, G. (eds) Endocrinology of the Heart. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83858-3_45
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DOI: https://doi.org/10.1007/978-3-642-83858-3_45
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