Abstract
ANF is a polypeptide with important influence on blood pressure, cardiac output and sodium excretion. As the physiological stimulus for ANF release right atrial volume, i.e. right atrial distension has been demonstrated in animals [3, 4] and patients [5, 7]. Significant changes in ANF serum level have been reported during CPB [2]: after onset of CPB ANF level rises and stays elevated. During CPB RAP is very low or negative so that right atrial distension cannot account for this increase in secretion. Aim of this study was to determine if the inversion of the right atrium during CPB causes the increased release of ANF.
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References
Deth RC, Wong K, Fukozawa S, Roco R, Smart JL, Lynch CJ, Awad R (1982) Inhibition of rat aorta contractile response by natriuresis-inducing extract of rat atrium. Fed Proc 41: 983
Dewar ML, Walsh G, Chiu RC-J, Kochamba K, Gutkowska J, Genest J, Cantin M (1986) Short Communications Atrial natriuretic factor: response to cardiac operation. J Thorac Cardiovasc Surg 96: 266–270
Kleinert HD, Maack T, Atlas SA, Jauszewicz A, Sealey JE, Laragh JH (1984) Atrial natriuretic factor inhibits angiotensin-, norepinephrine and potassium induced vascular contractility. Hypertension 6 [Suppl I]: 143–147
Lang RE, Tholken H, Ganten D, Luft FC, Ruskoaho H, Unger T (1985) Atrial natriuretic factor — a circulating hormone stimulated by volume loading. Nature 314: 264–266
Matsubara H, Nishihawa M, Umeda Y, Taniguchi T, Iwasaka T, Kurimoto T, Yamane Y, Inada M (1987) The role of atrial pressure in secreting atrial natriuretic polypeptides. Am Heart J 113 (6): 1457–1462
Richards AM, Nicholls MG, Ikram H, Webster MWI, Yandle TG, Espiner EA (1985) Renal, hemodynamic and hormonal effects of human alpha atrial natriuretic peptide in healthy volunteers. Lancet 1: 545–549
Rodeheffer RJ, Tanaka I, Imada T, Hollister AS, Robertson D, Inagami T (1986) Atrial pressure and secretion of atrial natriuretic factor into the human central circulation. JAAC 8 (1): 18–26
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© 1989 Springer-Verlag Berlin Heidelberg
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Dahm, M. et al. (1989). Right Atrial Inversion Causes Increased ANF Secretion During Cardiopulmonary Bypass. In: Kaufmann, W., Wambach, G. (eds) Endocrinology of the Heart. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83858-3_40
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DOI: https://doi.org/10.1007/978-3-642-83858-3_40
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-51409-1
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