Atrial Natriuretic Peptide (ANP) Protects Cells against Injury by Hypoxia and Hypochlorous Acid
Recent reports show that ANP protects against post-ischemic renal failure in vivo and in the isolated perfused kidney [4, 8]. Since ANP has been shown to be a potent renal vasodilatator, this protective effect may be mediated exclusively by improving hemodynamics. To determine if ANP also has a protective effect at the cellular level, studies were performed in hepatocyte cell cultures. Hepatocytes showed a considerable increase in cellular cGMP content after ANP stimulation, suggesting the presence of ANP receptors. Cell cultures were exposed to hypoxia and reactive oxygen (hypochlorous acid, HClO), which cause cell damage similar to postischemic injury in vivo . The following report demonstrates that ANP can protect cell cultures.
Key wordsAtrial natriuretic peptide Cell protection Hypoxia Reactive oxygen
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