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Atrial Natriuretic Peptide and Chronic Renal Failure

  • Conference paper
Endocrinology of the Heart

Summary

Experimental and clinical studies are reviewed on the role of atrial natriuretic peptide in fluid volume and cardiovascular homeostasis in chronic renal failure. In patients with end-stage renal disease, atrial natriuretic peptide is elevated prior to hemodialysis and lowered by hemodialysis, hemofiltration or ultrafiltration. Volume overload is the most important stimulus for elevation of plasma ANP in chronic renal failure, and concomitant cardiac enlargement and arterial hypertension may play a role.

Plasma ANP does not contribute to longterm regulation of sodium homeostasis, but is released in an exaggerated manner in response to acute volume load in chronic renal failure. Plasma ANP is a useful index of volume overload in patients with chronic renal failure.

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References

  1. Anderson JV, Raine AEG, Proudler A, Bloom SR (1980) Effect of haemodialysis on plasma concentrations of atrial natriuretic peptide in adult patients with chronic renal failure. J Endocr 110: 193–196

    Article  Google Scholar 

  2. Cannella G, Rodella A, Brunori G, Gaggiotti M, Sandrini M, Maiorca R (1987) Plasma concentrations of atrial natriuretic peptide in relation to body fluid status in chronic uraemia. Nephrol Dial Transplant 2: 158–160

    PubMed  CAS  Google Scholar 

  3. Cole BR, Kuhnline MA, Needleman P (1985) Atriopeptin III — A potent natriuretic, diuretic, and hypotensive agent in rats with chronic renal failure. J Clin Invest 76: 2413–2415

    Article  PubMed  CAS  Google Scholar 

  4. Czekalski S, Michel C, Dussaule JC, Touraine P, Mignon F, Ardaillou R (1988) Atrial natriuretic peptide and adaption of sodium urinary excretion in patients with chronic renal failure. Clin Sci 75: 243–249

    PubMed  CAS  Google Scholar 

  5. Deray G, Maistre G, Basset JY, Cacoub P, Carayon A, Anouar M, Baumelou A, Legrand JC, Ancri D, Jacobs C (1988) Plasma levels of atrial natriuretic peptide in chronically dialyzed patients. Kidney Int 34 [Suppl 25]: S86 - S88

    Google Scholar 

  6. Eisenhauer T, Talartschik J, Scheler F (1986) Detection of fluid overload by plasma concentration of human atrial natriuretic peptide (h-ANP) in patients with renal failure. Klin Wochenschr 65 [Suppl VI]: 68–72

    Google Scholar 

  7. Espiner EA, Nicholls MG, Yandle TG, Crozier IG, Cuneo RC, McCormick D, Ikram H (1986) Studies on the secretion, metabolism and action of atrial natriuretic peptide in man J Hypertens 4 [Suppl 2]: S85–S91

    CAS  Google Scholar 

  8. Goetz KL (1988) Physiology and pathophysiology of atrial peptides. Am J Physiol 254: E1 - E15

    PubMed  CAS  Google Scholar 

  9. Hasegawa K, Matsushita Y, Inoue T, Morii H, Ishibashi M, Yamaji T (1986) Plasma levels of atrial natriuretic peptide in patients with chronic renal failure. J Clin Endocrinol Metab 63: 819–822

    Article  PubMed  CAS  Google Scholar 

  10. Hodsman GP, Jackson B, Debrevi LM, Ogawa K, Johnston CI (1987) Atrial natriuretic factor in chronic renal failure: Studies in man and the rat. Clin Exp Pharmacol Physiol 14: 247–251

    Article  PubMed  CAS  Google Scholar 

  11. Jahn H, Schohn D, Schmitt R (1981) Hemodynamic studies in chronic terminal renal insufficiency — Effects of hemodialysis, hemofiltration and ultrafiltration procedures. Nephrologie 2: 53–62

    PubMed  CAS  Google Scholar 

  12. Luft FC, Lang RE, Aronoff GR, Ruskoaho H, Toth M, Ganten D, Sterzel RB, Unger T (1986) Atriopeptin III kinetics and pharmacodynamics in normal and anephric rats. J Pharmacol Exp Ther 236: 416–418

    PubMed  CAS  Google Scholar 

  13. Luft FC, Sterzel RB, Lang RE, Trabold EM, Veelken R, Ruskoaho H, Gao Y, Ganten D, Unger T (1986) Atrial natriuretic factor determinations and chronic sodium homeostasis. Kidney Int 29: 1004–1010

    Article  PubMed  CAS  Google Scholar 

  14. Morris M, Cain M, Russell A, Elliott J, Chalmers J (1987) Direct radioimmunoassay of human plasma atrial natriuretic peptide in various normal and pathophysiological states: Increase in renal and cardiac failure during exercise. Clin Exp Hypertens A9: 703–718

    Article  Google Scholar 

  15. Needleman PH, Greenwald (1986) Atriopeptin: A cardiac hormone intimately involved in fluid, electrolyte, and blood-pressure homeostasis. N Engl J Med 314: 828–834

    Article  PubMed  CAS  Google Scholar 

  16. Pacher R, Frass M, Hartter E, Woloszczuk W, Leithner C (1986) Continuous pump-driven hemofiltration associated with a decline in alpha-atrial natriuretic peptide. Crit Care Med 14: 1010–1014

    Article  PubMed  CAS  Google Scholar 

  17. Predel HG, Bäcker A, Kipnowski J, Düsing R, Kramer HJ (1987) Relationship of plasma concentrations of human atrial natriuretic peptide to renal function and blood pressure in patients with progressive chronic renal failure. Klin Wochenshcr 65 [Suppl VIII]: 127–132

    Google Scholar 

  18. Pruszczynski W, Viron B, Gzekalski S, Mignon F, Ardaillou R (1987) Role of cardiac parasympathetic dysfunction in atrial natriuretic peptide response to volume changes in patients with chronic renal failure. Mineral Electrolyte Metab 13: 333–339

    CAS  Google Scholar 

  19. Rascher W, Bald M, Kreis J, Tulassay T, Heinrich U, Schärer K (1987) Atrial natriuretic peptide in infants and children. Hormone Res 28: 58–63

    Article  PubMed  CAS  Google Scholar 

  20. Rascher W, Bald M, Kröner F, Tulassay T, Müller-Wiefel DE (1988) Klinische Wertigkeit der Messung des atrialen natriuretischen Peptids im Plasma von Kindern mit chronischer Nierensuffizienz. Z Kardiol 7 [Suppl 2]: 61–64

    Google Scholar 

  21. Rascher W, Tulassay T, Lang RE (1985) Atrial natriuretic peptide in plasma of volume-overloaded children with chronic renal failure. Lancet II: 303–305

    Google Scholar 

  22. Saxenhofer H, Gnädinger MP, Weidmann P, Shaw S, Schohn D, Hess C, Uehlinger DE, Jahn H (1987) Plasma levels and dialysance of atrial natriuretic peptide in terminal renal failure. Kidney Int 32: 554–561

    Article  PubMed  CAS  Google Scholar 

  23. Shenker Y, Port FK, Swartz RD, Gross MD, Grekin RJ (1987) Atrial natriuretic hormone secretion in patients with renal failure. Life Sci 41: 1635–1644

    Article  PubMed  CAS  Google Scholar 

  24. Smith S, Anderson S, Ballermann BJ, Brenner BM (1986) Role of atrial natriuretic peptide in adaption of sodium excretion with reduced renal mass. J Clin Invest 77: 1395–1398

    Article  PubMed  CAS  Google Scholar 

  25. Talartschik J, Eisenhauer T, Voth E, Sold G, Scheler F (1988) Ist der Plasma-ANP-Spiegel ein Index für die Volumenexpansion bei Dialysepatienten? Z Kardiol 77 [Suppl 2]: 72–77

    PubMed  Google Scholar 

  26. Wilkins MR, Wood JA, Adu D, Lote CJ, Kendall MJ, Michael J (1986) Change in plasma immunoreactive atrial natriuretic peptide during sequential ultrafiltration and haemodialysis. Clin Sci 71: 157–160

    PubMed  CAS  Google Scholar 

  27. Yamamoto Y, Higa T, Kitamura K, Tanaka K, Kangawa K, Matsuo H (1985) Plasma concentration of atrial natriuretic polypeptide in chronic hemodialysis patients. Regulatory Peptides 4 [Suppl]: 110–112

    CAS  Google Scholar 

  28. Yamamoto Y, Higa T, Kitamura K, Tanaka K, Kangawa K, Matsuo H (1987) Plasma concentration of human atrial natriuretic polypeptide in patients with impaired renal function. Clin Nephrol 27: 84–86

    PubMed  CAS  Google Scholar 

  29. Yandle TG, Richards AM, Nicholls MG, Cuneo R, Espiner EA, Livesey JH (1986) Metabolic clearance rate and plasma half life of alpha-human atrial natriuretic peptide in man. Life Sci 38: 1827–1833

    Article  PubMed  CAS  Google Scholar 

  30. Zoccali C, Ciccarelli M, Mallamaci F, Delfino D, Salnitro F, Parlongo S, Maggiore Q (1986) Effect of ultrafiltration on plasma concentrations of atrial natriuretic peptide in haemodialysis patients. Nephrol Dial Transplant 1: 188–191

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Universitätsklinik für Kinder- und Jugendmedizin (GHS), Essen, Germany

    W. Rascher & M. Bald

Authors
  1. W. Rascher
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  2. M. Bald
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Editors and Affiliations

  1. Medizinische Klinik II und Poliklinik der Universität, Ostmerheimer Straße 200, D-5000, Köln 91, Germany

    W. Kaufmann  & G. Wambach  & 

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© 1989 Springer-Verlag Berlin Heidelberg

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Rascher, W., Bald, M. (1989). Atrial Natriuretic Peptide and Chronic Renal Failure. In: Kaufmann, W., Wambach, G. (eds) Endocrinology of the Heart. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83858-3_14

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  • DOI: https://doi.org/10.1007/978-3-642-83858-3_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51409-1

  • Online ISBN: 978-3-642-83858-3

  • eBook Packages: Springer Book Archive

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