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Atrial Natriuretic Peptide and Chronic Renal Failure

  • W. Rascher
  • M. Bald
Conference paper

Summary

Experimental and clinical studies are reviewed on the role of atrial natriuretic peptide in fluid volume and cardiovascular homeostasis in chronic renal failure. In patients with end-stage renal disease, atrial natriuretic peptide is elevated prior to hemodialysis and lowered by hemodialysis, hemofiltration or ultrafiltration. Volume overload is the most important stimulus for elevation of plasma ANP in chronic renal failure, and concomitant cardiac enlargement and arterial hypertension may play a role.

Plasma ANP does not contribute to longterm regulation of sodium homeostasis, but is released in an exaggerated manner in response to acute volume load in chronic renal failure. Plasma ANP is a useful index of volume overload in patients with chronic renal failure.

Key words

Atrial natriuretic peptide Chronic renal failure Continuous ambulatory peritoneal dialysis Hemodialysis Hemofiltration Volume overload 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • W. Rascher
    • 1
  • M. Bald
    • 1
  1. 1.Universitätsklinik für Kinder- und Jugendmedizin (GHS)EssenGermany

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