Advertisement

Benign Neurogenic Tumors

  • Jean-Noël Bruneton

Abstract

Neurogenic tumors of the gastrointestinal tract are rare pathologic entities. Four types with variable frequencies have been identified. The two most common are the schwannoma, which is usually solitary and always encapsulated and the neurofibroma, which commonly occurs as multiple lesions in von Recklinghausen’s disease. Their frequency is undoubtedly overestimated because of problems for histologic differential diagnosis of large lesions from leiomyoma, which is much more common (Wood 1967). Nevertheless, these two neurogenic tumors merit consideration together as far as imaging is concerned because they have no specific differential features. The third form, ganglioneuroma, is exceptional (Wood 1967). The last type, granular cell tumor, has also been referred to as granular cell myoblastoma, an inexact term dating back to when this lesion was thought to derive from muscle. Histochemical studies have since demonstrated the neural origin of this tumor (Aparicio and Lumdsen 1969; Fischer and Wechsler 1962; Lack et al. 1980; Stefansson and Wollmann 1982), which is described in the end of this chapter, after solitary gastric and intestinal neurogenic tumors. Esophageal and colorectal lesions are exceptional.

Keywords

Schwann Cell Carcinoid Tumor Granular Cell Barium Study Granular Cell Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abel ME, Kingsley AEN, Abcarian H, Arlenga P, Barron SS (1985) Anorectal neurilemmomas. Dis Colon Rectum 28: 960–961PubMedCrossRefGoogle Scholar
  2. Aparicio SR, Lumdsen CE (1969) Light and electron microscope studies on granular cell myoblastoma of the tongue. J Pathol 97: 339–355PubMedCrossRefGoogle Scholar
  3. Baldi A, Azzario G, Merli G (1979) Le localizzazioni digestive della neurofibromatosi di Recklinghausen. Minerva Chir 34: 363–374Google Scholar
  4. Balintffy J, Thurzo R (1962) A duodenal neurinoma developed around metal foreign bodies. Gastroenterologia (Basel) 98: 354–359Google Scholar
  5. Barber PV (1976) Carcinoid tumor of the ampulla of Vater associated with cutaneous neurofibromatosis. Postgrad Med 52: 514–517CrossRefGoogle Scholar
  6. Beck DE, Wheeler RA, Smith MD (1986) Gastric neurofibroma in an adolescent. South Med J 79: 359–361PubMedCrossRefGoogle Scholar
  7. Berk PN, Scher GS, Bode DF (1971) Unusual tumors of the gastrointestinal tract. MR 113: 159–170Google Scholar
  8. Bottger E, Dittmar D, Senft KP, Burghard A, Asmar F, Hartmann R (1973) Seltene Duodenaltumoren und ihre Differentialdiagnose. Fortschr Geb Roentgenstr 119: 17–25CrossRefGoogle Scholar
  9. Brasfield RD, Das Gupta TK (1972) Von Recklinghausen’s disease: a clinicopathological study. Ann Surg 175: 86–104PubMedCrossRefGoogle Scholar
  10. Brette R, Saubier E, Tissot-Favre A, Gaillard P, Phelip E (1969) Schwannomes duodénaux. A propos de deux observations anatomocliniques dont une avec explorations vasculaires. Arch Fr Mal Appar Dig 58: 359–368Google Scholar
  11. Brunet JP, Bensahel H, Boureau M (1971) Schwan-nome gastrique chez l’enfant (à propos d’une observation). Ann Chir Infant 12: 297–302PubMedGoogle Scholar
  12. Bruneton JN, Drouillard J, Roux P, Ettore F, Lecomte P (1983) Neurogenic tumors of the stomach. Report of 18 cases and review of the literature. Fortschr Geb Roentgenstr 2: 192–198CrossRefGoogle Scholar
  13. Bruneton JN, Drouillard J, Roux P, Ettore F, Aubanel D (1984) Les tumeurs nerveuses de l’intestin grêle. Revue de la littérature à propos de 6 cas personnels. Ann Gastroenterol Hepatol (Paris) 20: 79–84Google Scholar
  14. Bucker J, Stossel HG (1961) Übergutartige Magentumoren. Fortschr Geb Roentgenstr 94: 159–175CrossRefGoogle Scholar
  15. Burns DK, Silva FG, Forde KA, Mount PM, Clark HB (1983) Primary melanocytic schwannoma of the stomach. Evidence of dual melanocytic and Schwannian differentiation in an extra-axial site in a patient without neurofibromatosis. Cancer 52: 1432–1471Google Scholar
  16. Cachin M, Pergola F, Terris G, Roques R (1959) Schwannomes multiples du tube digestif. Arch Fr Mal Appar Dig 48: 821–829Google Scholar
  17. Capdeville R, Bennet J, Dubois F, Toulet J (1970) L’artériographie des tumeurs du grêle. A propos de 3 cas de schwannomes. Arch Fr Mal Appar Dig 59: 453–462Google Scholar
  18. Carlson HC, Good CA (1973) Neoplasms of the small intestine. In: Margulis A, Burhenne H (eds) Alimentary tract roentgenology, 2nd edn. Mosby, Saint Louis, pp 865–902Google Scholar
  19. Cedermak J (1949) Neurinomas of the gastrointestinal tract. J Int Coll Surg 12: 5–11Google Scholar
  20. Cone JB, Wetzsel WJ (1982) Esophageal granular cell tumors: report of two multicentric cases with observation on their histories. J Surg Oncol 20: 14–16PubMedCrossRefGoogle Scholar
  21. Coutinho DS de S, Soga J, Yoshikawa T, Miyashita K, Tanaka O, Sasaki K, Muto T, Shimizu T (1985) Granular cell tumors fo the esophagus: a report of two cases and review of the literature. Am J Gastroenterol 80: 758–762Google Scholar
  22. Croker JR, Greenstein RJ (1976) Malignant schwannosarcoma of the stomach in a patient with von Recklinghausen’s disease. Histopathology 3: 79–85CrossRefGoogle Scholar
  23. Crowe FW, Shull WJ, Neel JW (1956) A clinical pathological and genetic study of multiple neurofibromatosis. Thomas, SpringfieldGoogle Scholar
  24. Davis GB, Berk RN (1973) Intestinal neurofibromas in von Recklinghausen’s disease. Am J Gastroenterol 60: 410–414PubMedGoogle Scholar
  25. Debray C, Hardouin JP, Gouin B, Marche C (1971) Les localisations digestives de la maladie de Recklinghausen. Gaz Med Fr 78: 965–974Google Scholar
  26. De Cllverra FJ, Cabral Silveira JM, Martins MI, Marthinho F, Soares F, De Oliveira F (1986) Schwannomas gastricos. A proposito de cinco casos siendo tres malignos. Rev Esp Enferm Apar Dig 69: 124–128Google Scholar
  27. De Schepper A, Hubens A, Van Vooren W, Verbraeken H (1974) Angiography in diagnosis of small bowel tumors. Radiologe 14: 425–430PubMedGoogle Scholar
  28. Dupuy R, Vallin J, Henry JG (1962) Schwannome gastrique associé à un épithélioma glandulaire. Arch Fr Mal Appar Dig 51: 166–169Google Scholar
  29. Dupuy R, Vallin J, Guenin P, Coldefy JM, Bernard J (1969) Invagination intestinale par tumeur bénigne du grêle. Schwannome et histiocytofibrome. Arch Fr Mal Appar Dig 58: 582–583Google Scholar
  30. Elhadad A, Piquet F, Slama JL, Godefroy Y, Pau-gam B (1984) La tumeur à cellules granuleuses de l’oesophage. Revue de la littérature. A propos de 1 cas. Ann Chir 38: 441–445PubMedGoogle Scholar
  31. Finkel M, Finkel F, Harris A (1978) Von Recklinghausen’s disease with involvement of the colon. An endoscopic view. Mt Sinai J Med 45: 387–389Google Scholar
  32. Fisher ER, Wechsler H (1962) Granular cell myoblastoma: a misnomer. Electron microscopic and histochemical evidence concerning its Schwann cell derivation and nature (granular cell schwan-noma). Cancer 15: 936–954Google Scholar
  33. Fujii K, Yamagata S, Suzuki J, Sasaki R, Shoji T, Makabe M, Memezawa H (1972) Angiographic features of submucosal tumours of the stomach. Tohoku J Exp Med 107: 287–299PubMedCrossRefGoogle Scholar
  34. Geindre M, Coulomb M, Crouzet G, Marty F (1969) Artériographie mésentérique supérieure et tumeurs hémorragiques du grêle. Sem Hop 45: 1634–1639PubMedGoogle Scholar
  35. Gilly G (1971) Neurinom der Pars descendens du- odeni. Fortschr Geb Roentgenstr 115: 126–128CrossRefGoogle Scholar
  36. Goldman RC (1968) Ganglioneuroma of the duodenum. Relationship to nonchromaffin paraganglioma of the duodenum. Am J Surg 115: 716–719PubMedCrossRefGoogle Scholar
  37. Good AC (1963) Tumors of the small intestine. Caldwell lecture 1962. AJR 89: 685–705Google Scholar
  38. Grafe W, Thorbjarnarson B, Pearce JM, Beal JM (1960) Benign neoplasms of the stomach. Am J Surg 100: 561–571PubMedCrossRefGoogle Scholar
  39. Gregl A, Nieman H, Schlachetzki J (1968) Klinische Symptomatik neurogener Magentumoren. Bruns Beitr Klin Chir 216: 640–643PubMedGoogle Scholar
  40. Grosdidier J, Guibal F (1969) Schwannome de l’estomac. Sem Hop 45: 1187–1188PubMedGoogle Scholar
  41. Hassell P (1982) Gastrointestinal manifestations of neurofibromatosis in children. A report of two cases. J Assoc Can Radiol 33: 202–204Google Scholar
  42. Hecker HA (1959) Beitrag zum Neurinom des Magen-Darm-Kanals. Gastroenterologia 91: 266–274CrossRefGoogle Scholar
  43. Hill K, Schmitt-Koppler A (1972) Zur Klinik und Histogenese der neurogenen Tumoren des oberen Gastrointestinaltrakts. Dtsch Med (Wochenschr) 97: 899–902CrossRefGoogle Scholar
  44. Hochberg FH, Dasilva AB, Galdabini J, Richardson EP (1974) Gastrointestinal involvement in von Recklinghausen’s neurofibromatosis. Neurology 24: 1144–1151PubMedGoogle Scholar
  45. Hofer D (1977) Über Neurinome des Magens. Chirurg 48: 185–188PubMedGoogle Scholar
  46. Hough DR, Chan A, Davidson H (1983) Von Recklinghausen’s disease associated with gastrointestinal carcinoid tumors. Cancer 51: 2206–2208PubMedCrossRefGoogle Scholar
  47. Jenett M, Longin F, Ludwig J (1983) Neurinom des Magens. Fortschr Geb Roentgenstr 137: 362–364CrossRefGoogle Scholar
  48. Johnson L, Weaver M (1981) Von Recklinghausen’s disease and gastrointestinal carcinoids. JAMA 245: 2496Google Scholar
  49. Johnston J, Helwig EB (1981) Granular cell tumors of the gastrointestinal tract and perianal region. Dig Dis Sci 26: 807–816PubMedCrossRefGoogle Scholar
  50. Jouanneau P, Teniere P, Geffroy Y (1974) Localisations digestives de la maladie de Recklinghausen. A propos d’un cas. Chirurgie 100: 558–565Google Scholar
  51. Juan IK, Sono F, Okada T, Muto M, Furuki A (1980) Neurogenic tumor of small intestine, report of a case with review of literature. Gastroenterol Jpn 15: 112–119PubMedGoogle Scholar
  52. Jurja J (1971) Schwannomes gastriques multiples. J Radiol 52: 387–388Google Scholar
  53. Klatte EC, Franken EA, Smith JA (1976) The radiographic spectrum in neurofibromatosis. Semin Roentgenol 11: 17–33PubMedCrossRefGoogle Scholar
  54. Klepping C, Cortet P, Michiels R, Dusserre P, Jacquot B, Gaudet M, Michelot M (1965) Les schwannomes de l’intestin grêle (revue de la littérature à propos de deux observations personnelles). J Med Lyon 46: 1607–1632PubMedGoogle Scholar
  55. Krivine JM, Hivet M, Levame M (1964) Les tumeurs apparemment bénignes du duodenum. Ann Chir 18: 588–609PubMedGoogle Scholar
  56. Kron B (1971) Schwannome malin de l’épiploon gastrocolique. Sem Hop 47: 2684–2685PubMedGoogle Scholar
  57. Lack EE, Worscham GF, Callihan MD, Crawford BE, Kappenbach S, Rowden GR, Chun B (1980) Granular cell tumor: a clinicopathologic study of 110 patients. J Surg Oncol 13: 301–316PubMedCrossRefGoogle Scholar
  58. Lagadec B, Blondin G, Van Haecke P (1979) Schwannome exogastrique bénin géant. Artériographie sélective des artères digestives. Med Chir Dig 8: 171–172Google Scholar
  59. Lemaitre G, L’Hermine C, Proye C, Marache P, Ribet M (1976) Aspect radiologique des schwan-nomes du 2ème duodénum à développement extrinsèque (à propos de 3 observations). Lille Med 21: 827–832PubMedGoogle Scholar
  60. Leroy A, Blanc P, Henry J (1962) Etude analytique des schwannomes digestifs. A propos d’une statistique de 72 cas de schwannomes. J Chir 83: 683–708Google Scholar
  61. Lifrange M (1969) A propos des léiomyomes et des neurinomes de l’intestin grêle. Rev Med Liege 24: 769–772PubMedGoogle Scholar
  62. Lohrmann A, Kottmann F, Donhuijsen K, Goebell H, Weichert HC (1981) Dunndarm-NeurofibromGoogle Scholar
  63. morlans Recklinghausen als Ursache rezidivierender gastrointestinaler Blutungen. Leber Magen Darm 11: 132–135Google Scholar
  64. Lukash WM, Morgan RI, Sennett CO, Nielson OF (1966) Gastrointestinal neoplasms in von Recklinghausen’s disease. Arch Surg 92: 905–908PubMedCrossRefGoogle Scholar
  65. Madrid G, Pardo J, Perez C, Pereda RG, Galbe R, Ros LH, Soler A, Navarro ML, Valero I, Almajano C (1986) The neurofibroma of the oesophagus. Eur J Radiol 6: 67–69PubMedGoogle Scholar
  66. Mazare Y, Champetier J, Micoud M, Verdier JM (1968) Localisation appendiculaire de la neurofibromatose. Rev Lyon Med 17: 601–608PubMedGoogle Scholar
  67. Ming SC (1973) Tumors of the esophagus and stomach. Atlas of tumor pathology, 2nd series, fasc 7. AFIP, WashingtonGoogle Scholar
  68. Nardi P, Biagi P, Poggini M, Brettoni A, Bombagli A (1986) Il ruolo dell’ ultrasonografia nella diagnosi delle neoplasie non epiteliali dello stomaco. Considerazioni a proposito di due casi. Radiol Med 72: 977–978Google Scholar
  69. Nillson B, Jonsson I (1957) Malignant neurinoma of the duodenum. Report of a case and review of the literature. Acta Chir Scand 113: 357–363Google Scholar
  70. Ochsner SF, Janetos GP (1965) Benign tumors of the stomach. JAMA 191: 881–886PubMedCrossRefGoogle Scholar
  71. O’Connell DJ, McMahon H, De Meester TR (1978) Multicentric tracheobronchial and esophageal granular cell myoblastoma. Thorax 33: 596–602PubMedCrossRefGoogle Scholar
  72. Ostermiller W, Joergenson EJ, Weibe L (1966) A clinical review of tumors of the small bowel. Am J Surg 111: 403–409PubMedCrossRefGoogle Scholar
  73. Pape R, Hackensellner HA (1952) Das röntgenologische Erscheinungsbild der neurogenen Tumoren des Verdauungstrakts. Fortschr Geb Roentgenstr 76: 691–711CrossRefGoogle Scholar
  74. Paskin DL, Hull JD, Cookson PS (1972) Granular cell myoblastomas: a comprehensive review of 15-years experience. Ann Surg 175: 501–504PubMedCrossRefGoogle Scholar
  75. Perea VD, Gregory JL (1962) Neurofibromatosis of the stomach. Report of a case associated with vonGoogle Scholar
  76. Recklinghausen’s disease and review of the literature. JAMA 182: 259–263Google Scholar
  77. Peycelon R, Replumaz P (1958) A propos des schwannomes gastriques. Arch Fr Mal Appar Dig 47: 465–479Google Scholar
  78. Pinto ADS, Novo JA (1985) Gastric neurilemmoma: case report. Mt Sinai J Med 52: 647–649PubMedGoogle Scholar
  79. Plachta A (1962) Benign tumors of the esophagus. Review of literature and report of 99 cases. Am J Gastroenterol 38: 639–652PubMedGoogle Scholar
  80. Popesco-Urlueni M (1962) A propos des schwan-nomes de l’intestin grêle. Arch Fr Mal Appar Dig 51: 1120–1131Google Scholar
  81. Proff E, Hill K, Schmitt-Koppler A (1972) Zur Klinik und Histogenese der neurogenen Tumoren des oberen Gastrointestinaltraktes. Dtsch Med Wochenschr 97: 899–902CrossRefGoogle Scholar
  82. Reichelt H (1973) Ein aussergewöhnlicher Fall einer Neurofibromatosis von Recklinghausen mit Röntgenologischem Nachweis von Krankheitsmanifestationen an Thorax, Mediastinum, Schädel, Osophagus, Magen und Kolon. Rontgenblatter 26: 361–366PubMedGoogle Scholar
  83. River L, Silverstein J, Tope JW (1956) Collective review: benign neoplasms of small intestine. A critical comprehensive with reports of 20 new cases. Int Abstr Surg 102: 1–38Google Scholar
  84. Rosner D, Hivet M, Lagadec B, Conte J (1973) Schwannomes multiples à localisation digestive (maladie de von Recklinghausen). A propos d’un cas familial. Med Chir Dig 2: 39–44Google Scholar
  85. Sandler RS, Wood DR, Bozymski EM (1981) Endoscopie removal of a granular cell tumor of the esophagus. Gastroenterol Endosc 27: 70–72CrossRefGoogle Scholar
  86. Schwartz DT, Gaetz HP (1965) Multiple granular cell myoblastomas of the stomach. Am J Clin Pathol 44: 453–457PubMedGoogle Scholar
  87. Sivak MV, Sullivan BH, Farmer RG (1975) Neuro-genic tumor of the small intestine. Review of the literature and report of a case with endoscopie removal. Gastroenterology 68: 374–380Google Scholar
  88. Sobbe A, Voelker D (1972) Das Neurofibrom des Dünndarms. Fortschr Geb. Roentgenstr 116: 572–574Google Scholar
  89. Stefansson K, Wollmann RL (1982) S-100 protein in granular cell tumors (granular cell myoblastomas). Cancer 49: 1834–1838PubMedCrossRefGoogle Scholar
  90. Strong EW, Mc Divitt RW, Brasfield RD (1970) Granular cell myoblastoma. Cancer 25: 415–422PubMedCrossRefGoogle Scholar
  91. Tate RW, Furaso WJ (1948) Neurofibroma of the stomach. Am J Surg 75: 607–613PubMedCrossRefGoogle Scholar
  92. Totterman S, Lindfors O, Nickels J (1980) A schwannoma of the lesser omentum. Fortschr Geb Roentgenstr 132: 585–586CrossRefGoogle Scholar
  93. Uflacker R, Alves MA, Diehl JC (1985) Gastrointestinal involvement in neurofibromatosis: angiographic presentation. Gastrointest Radiol 10: 163–165PubMedCrossRefGoogle Scholar
  94. Vachon A, Chattot R, Pasquier J, Aimard G (1959) Nouvelle observation de schwannomes digestifs associés à une maladie de Recklinghausen. Arch Fr Mal Appar Dig 48: 836–838Google Scholar
  95. Von Koppenfels R (1975) Neurome und Myome des Magens. Fortschr Geb Roentgenstr 122: 164–166CrossRefGoogle Scholar
  96. Vujic I, Sbrocchi RD, Standley JH, Seymour EQ (1983) Angiographic demonstration of gastrointestinal neurofibromas in von Recklinghausen’s disease. Gastrointest Radiol 8: 283–284PubMedCrossRefGoogle Scholar
  97. Vuyk HD, Snow GB, Tiwari RM, Van Velsen D, Veldhuizen RW (1985) Granular cell tumor of the proximal esophagus. A rare disease. Cancer 55: 445–449Google Scholar
  98. Weston SD, Marren M, Cohan MH, Schlachter IS (1963) Neurofibroma of the rectum and colon. J Int Coll Surg 40: 285–293PubMedGoogle Scholar
  99. Will C, Hering K (1978) Neunnom des Dunndarms. Fortschr Roengenstr 129: 646–647CrossRefGoogle Scholar
  100. Willis RA (1962) The borderland of embryology and pathology. 2nd edn. Butterworths, WashingtonGoogle Scholar
  101. Winter J, Schubert GE, Greiner L, Prohm P (1984) Das Magenneurinom. Leber Magen Darm 14: 164–168PubMedGoogle Scholar
  102. Wissmann C, Appel W (1977) Exulzeriertes Neurofibrom des Magens. Fortschr Geb Roentgenstr 127: 77–78CrossRefGoogle Scholar
  103. Wood DA (1967) Tumors of the intestines. Atlas of tumor pathology, sect 6, fasc 22. AFIP, WashingtonGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Jean-Noël Bruneton
    • 1
  1. 1.Service de RadiologieCentre Antoine-lacassagneNice CedexFrance

Personalised recommendations