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Hormone-Related Malignant Tumors pp 41–47Cite as

Medullary Carcinoma of the Thyroid

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 118))

Abstract

Medullary carcinoma (MC) originates in the C cells of the thyroid gland. Among the epithelial malignancies of this organ it accounts for some 3%–12% (Deftos 1983). Hazard et al. (1959) were the first to define it as a separate entity on the basis of amyloid deposits in the stroma. MC occurs in familial or sporadic form and with an approximately balanced sex distribution (Williams 1979; Deftos 1983; Emmertsen 1985). Its clinical course is characterized by a marked variability in morphologic structure and duration of disease (between a few months and several decades; Deftos 1983). Neither histologic nor cellular variations of MC (Kakudo et al. 1979; Harach and Williams 1983; Landon and Ordonez 1985; Mendelsohn et al. 1980; Martinelli et al. 1983; Fernandes et al. 1982; Zaatari et al. 1983; Golouh et al. 1985; Marcus et al. 1982; Kracht 1977; Zeman et al. 1978) can be correlated with the prognostic outlook, but morphologic differences are of distinctive significance for separating MC from the other types of thyroid carcinoma.

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Author information

Authors and Affiliations

  1. Gerhard-Domagk-Institut für Pathologie, Universität Münster, Domagkstraße 17, 4400, Münster, Germany

    W. Böcker

  2. Institut für Pathologie, Universität Hamburg, Martinistraße 52, 2000, Hamburg 20, Germany

    S. Schröder

Authors
  1. W. Böcker
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  2. S. Schröder
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Editor information

Editors and Affiliations

  1. Frauenklinik, Medizinische Einrichtungen, Universität Düsseldorf, Moorenstraße 5, 4000, Düsseldorf, Germany

    Lutwin Beck

  2. Gerhard Domagk-Institut für Pathologie, Westfälische Wilhelms-Universität Münster, Domagkstraße 17, 4400, Münster, Germany

    Ekkehard Grundmann

  3. Urologische Klinik, Universität Düsseldorf, Moorenstraße 5, 4000, Düsseldorf, Germany

    Rolf Ackermann

  4. Chirurgische Klinik und Poliklinik I, Universität Düsseldorf, Moorenstraße 5, 4000, Düsseldorf, Germany

    Hans-Dietrich Röher

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© 1990 Springer-Verlag Berlin·Heidelberg

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Böcker, W., Schröder, S. (1990). Medullary Carcinoma of the Thyroid. In: Beck, L., Grundmann, E., Ackermann, R., Röher, HD. (eds) Hormone-Related Malignant Tumors. Recent Results in Cancer Research, vol 118. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83816-3_5

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  • DOI: https://doi.org/10.1007/978-3-642-83816-3_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83818-7

  • Online ISBN: 978-3-642-83816-3

  • eBook Packages: Springer Book Archive

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