Abstract
The use of biological markers in the diagnosis and follow-up of patients with prostate cancer was pioneered by the work of Gutman et al. in 1936. In the intervening 50 years refinements in techniques and in the understanding of the physiological function of these normally occurring enzymes and proteins have enabled us to understand the potential and the problems associated with the use of these markers in clinical medicine. A review of biological markers in the prostate published previously by me (Pontes 1983) gave an extensive analysis of the value of specific and nonspecific markers in prostate cancer.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Chan DW, Bruzek D, Rock R, Waldron C (1986) evaluation of a monoclonal immunoradiometric assay for prostate-specific antigen. Clin Chem 32: 1125
Gutman E, Sproul E, Gutman A (1936) Significance of increased phosphatase activity of bone at the site of osteoplastic metastases secondary to carcinoma of the prostate gland. Am J Cancer 28: 485
Liedtke RJ, Batjer JD (1984) Measurement of prostate-specific antigen by radioimmunoassay. Clin Chem 30: 649–652
Oesterling JE, Chan DW, Epstein JI, Kimball AW, Bruzek DJ, Rock RC, Brendler CB Walsh PC (1987) Prostate specific antigen in the preoperative and postoperative evaluation of localized prostatic cancer treated with radical prostatectomy. J Urol 139: 766
Pontes JE (1983) Bological markers in prostate cancer. J Urol 130: 1037
Pontes JE, Jabalameli P, Montie J, Foemmel R, Howard PD; Boyett J (to be published), Disappearance rate of biological markers following radical prostatectomy —prognostic implications. Urology (to be published)
Stamey TA, Yang N, Hay AR, McNeal JE, Freiha F, Redwine E (1987) Prostate specific antigen as a serum marker for adenocarcinoma of the prostate. N Engl J Med 317: 909
Vihko PM, Schroeder FH, Lukkarinen O, Vihko R (1982) Secretion into and elimination from blood circulation of prostate specific acid phosphatase, measured by radioimmunoassay. J Urol 128: 202
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin·Heidelberg
About this paper
Cite this paper
Pontes, J.E. (1990). New Developments in Biological Markers in Prostate Cancer. In: Beck, L., Grundmann, E., Ackermann, R., Röher, HD. (eds) Hormone-Related Malignant Tumors. Recent Results in Cancer Research, vol 118. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83816-3_18
Download citation
DOI: https://doi.org/10.1007/978-3-642-83816-3_18
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-83818-7
Online ISBN: 978-3-642-83816-3
eBook Packages: Springer Book Archive