Clinical and Diagnostic Findings in Patients with Chromaffin Tumors: Pheochromocytomas, Pheochromoblastomas

  • H. Käser
Conference paper
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 118)

Abstract

Chromaffin tumors are defined as neoplasias composed of catecholamine-producing, -storing, and -secreting cells. They therefore develop not only in the adrenal medulla but also in sympathetic paraganglia. Regardless of their intra- or extra-adrenal localization, we shall use the term pheochromocytoma for all expansive growing forms of these tumors and the term pheochromoblastoma for all infiltrating and metastasizing forms (Table 1; Käser 1985). However, it must be emphasized that even the nonmalignant pheochromocytoma must be considered as lifethreatening disease. In fact, its endocrine activity may lead to death if the tumor remains unrecognized and untreated. However, if correctly diagnosed, this neural crest tumor can be removed by surgery, and most patients can thus be cured.

Keywords

Fatigue Dopamine Histamine Beach Norepinephrine 

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References

  1. Beierwaltes WH (1985) A new method of identifying pheochromocytoma and proving that a “mass” is a “Pheo”. J Urol 134: 105PubMedGoogle Scholar
  2. Beutter D, Chatal JF, Brunet G, Charbonnel B (1987) Treatment of malignant pheochromocytoma with I-131 metaiodobenzylguanidine. Ann Endocrinol 48: 53–57Google Scholar
  3. Bouvier JF, Maiassi N, Fleury MC, Mornex R, Lahneche BE (1987) Diagnosis and treatment of metastatic pheochromocytomas by I-131 MIBG. Tumour Biol 8: 362–363Google Scholar
  4. Bravo EL, Tarazi RC, Gifford RW, Steward BH (1979) Circulating and urinary catecholamines in pheochromocytoma. N Engl. J. Med. 301: 682–686PubMedCrossRefGoogle Scholar
  5. Chatal JF, Charbonnel B (1985) Comparison of jodobenzylguanidine imaging with computed tomography in locating pheochromocytoma. J. Clin. Endocrinol Metab 61: 769–772PubMedCrossRefGoogle Scholar
  6. Cordes U (1985) Nebennierenmark. In: Kümmerle F, Lenner V (eds) Erkrankungen der Nebennieren. Thieme, Stuttgart, pp 96–120Google Scholar
  7. Coupland RE (1965) The natural history of the chromaffin cell. Longmans, Green, LondonGoogle Scholar
  8. Coupland RE (1981) Catecholamine secreting tissues. In: Fotherby K, Pal SB (eds) Hormones in normal and abnormal human tissues, De Gruyter, Berlin, pp 589–633Google Scholar
  9. Fink IJ, Reining JW, Dwyer AJ, Doppman JL, Marston-Linehan W, Keiser HR (1985) MR—imaging of pheochromocytomas. J. Comput Assist Tomogr. 9: 454–458PubMedCrossRefGoogle Scholar
  10. Fischer M, Galanski M, Winterberg B, Vetter H (1985) Localization procedures in pheochromocytoma and neuroblastoma. Cardiology 72 (Suppl 1): 143–146PubMedCrossRefGoogle Scholar
  11. Fries JG, Chambertin JA (1968) Extra-adrenal pheochromocytoma: literature review and report of a cervical pheochromocytoma. Surgery 63: 268–279Google Scholar
  12. Gauer J.-M, Käser H, Zingg EJ (1988) Klinik, Diagnose und Therapie des Phäochromozytoms. Aktuel Urol 19: 7–12CrossRefGoogle Scholar
  13. Gifford RW, Bravo EL, Manger WM (1985) Diagnosis and management of pheochromocytoma. Cardiology 72 (Suppl 1): 126–130PubMedCrossRefGoogle Scholar
  14. Grunwald F, Ruhlmann J, Kozak B, Overlack A, Christ F, Hotze A, Biersack H (1988) I-131 labeled metaiodobenzylguanidine in the diagnosis and treatment of distant metastases of a pheochromocytoma. Dtsch Med Wochenschr 113: 297–299PubMedCrossRefGoogle Scholar
  15. Käser H, (1985) Pathophysiologie und Klinik des Phaeochromocytoms und des Phaeochromoblastoms. In: Hauri D, Schmucki O (eds) Erkrankungen der Nebenschilddrüsen und Nebennieren. Fischer, Stuttgart, pp 195–207Google Scholar
  16. Käser, H. (1987) Nebennierenmark-Funktion und -Störungen, In: Ziegler R (ed) Hormon-und Stoffwechselerkrankungen in der Praxis. Edition Medizin, Weinheim- Deerfield-Beach, Basel, pp 345–366Google Scholar
  17. Käser H, Wagner HP (1982) Chromaffin tumors in childhood: experiences with 29 cases. In: Pediatric Oncology. Excerpta Medica, AmsterdamGoogle Scholar
  18. Labhart A (1971) Das Nebennierenmark. In: Klinik der inneren Sekretion, Springer, Berlin Heidelberg New YorkGoogle Scholar
  19. Langmann J (1970) Medizinische Embryologie. Thieme, StuttgartGoogle Scholar
  20. Manger WM, Gifford RW (1977) Pheochromocytoma. Springer, Berlin Heidelberg New YorkCrossRefGoogle Scholar
  21. McDougall IR (1984) Malignant pheochromocytoma treated by I-131 MIBG. J. Nucl. Med. 25: 249PubMedGoogle Scholar
  22. Niklaus T (1986) Chromaffine Tumoren im Kindesalter. Inauguraldissertation, University of Berne, SwitzerlandGoogle Scholar
  23. Otto R (1983) Die Sonographie der Nieren, der ableitenden Harnwege und der Nebennieren. Schweiz. Rundsch Med Prax 72: 227–232PubMedGoogle Scholar
  24. Plouin PF, Duclos JM, Menard J, Comoy E, Bohuon C, Alexandre JM (1981) Biochemical tests for diagnosis of pheochromocytoma: urinary versus plasma determinations. Br Med J 282: 853–854CrossRefGoogle Scholar
  25. Robinson R (1980) Tumours that secrete catecholamines. Wiley, ChichesterGoogle Scholar
  26. Schmedtje JF, Sax S, Pool JL, Goldfarb RA, Nelson EB (1987) Localization of ectopic pheochromocytomas by magnetic-resonance imaging. J Med. 83: 770–772CrossRefGoogle Scholar
  27. Shapiro B, Copp JE, Sisson JC, Eyre PL, Beierwaltes WH (1985) 131–1 metaiodobenzyl-guanidine for the locating of suspected pheochromocytoma. Experience in 400 cases. J Nucl Med 26: 576–585PubMedGoogle Scholar
  28. Shulkin BL, Shen SW, Sisson JC, Shapiro B (1987) Iodine-131 MIBG scintigraphy of the extremities in metastatic pheochromocytoma and neuroblastoma. J Nucl Med 28: 315–318PubMedGoogle Scholar
  29. Stenström G, Svärdsudd K (1986) Pheochromocytoma in Sweden 1981–1985. Acta Med Scand 220: 225–232PubMedCrossRefGoogle Scholar
  30. Sutton MG St J, Sheps SG, Lie JT (1981) Prevalence of clinically unsuspected pheochromocytoma. Review of a 50-year autopsy series. Mayo Clin Proc 56: 354–360PubMedGoogle Scholar
  31. Tippett PA, West RS, McEwan AJ, Middleton JE, Ackery DM (1987) A comparison of dopamine and homovanillic acid excretion, as prognostic indicators in malignant phaeochromocytoma. Clin. Chim. Acta 166: 123–133PubMedCrossRefGoogle Scholar
  32. Ziegler W (1985) Diagnostik des Phäochromocytoms. In: Hauri D, Schmucki O (eds) Erkrankungen der Nebenschilddrüsen und Nebennieren. Fischer, Stuttgart, pp 208–216Google Scholar

Copyright information

© Springer-Verlag Berlin·Heidelberg 1990

Authors and Affiliations

  • H. Käser
    • 1
  1. 1.Institut für klinische und experimentelle TumorforschungUniversität BernBernSwitzerland

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