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Cellular Receptors of Hormones and Nonhormone Ligands in Normal and Malignant Cells

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Book cover Hormone-Related Malignant Tumors

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 118))

Abstract

The rate of cell division in multicellular organisms is controlled by humoral signals (e.g., hormones, growth factors, transport proteins or low-density lipoproteins), cell-to-cell interactions (e.g., contact inhibition), and cell-inherent factors such as certain genes and the associated gene products. Under physiological conditions there is a balance between creation and death of cells in response to requirement. For example, in case of local cell destruction fibroblasts, endothelia, pericytes, possibly keratinocytes, osteocytes, and other cell populations start to divide. Subsequent to repairment the cells stop growing. This process of growth regulation is under the control of various local signals. It is unclear up to now whether similar, but pathological, mechanisms also play a role in cell transformation with uncontrolled proliferation. Besides such local growth control many humoral factors are known to regulate cell proliferation. A prerequisite for the effectiveness of such growth-regulating substances are cellular receptors of the target cells through which the signals are transmitted into the cells to switch on and off the corresponding genes.

This work was supported by the Deutsche Forschungsgemeinschaft, SFB 232 (Hamburg) and grant Di 276/1–2, as well as by the Hamburger Krebsgesellschaft, the Hamburger Stiftung zur Förderung der Krebsbekämpfung and the Erich und Gertrud Roggenbruck-Stiftung.

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Authors and Affiliations

  1. Institut für Pathologie, Universitätskrankenhaus Eppendorf, Martinistraße 52, 2000, Hamburg 20, Germany

    M. Dietel & A. Niendorf

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  1. M. Dietel
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Editors and Affiliations

  1. Frauenklinik, Medizinische Einrichtungen, Universität Düsseldorf, Moorenstraße 5, 4000, Düsseldorf, Germany

    Lutwin Beck

  2. Gerhard Domagk-Institut für Pathologie, Westfälische Wilhelms-Universität Münster, Domagkstraße 17, 4400, Münster, Germany

    Ekkehard Grundmann

  3. Urologische Klinik, Universität Düsseldorf, Moorenstraße 5, 4000, Düsseldorf, Germany

    Rolf Ackermann

  4. Chirurgische Klinik und Poliklinik I, Universität Düsseldorf, Moorenstraße 5, 4000, Düsseldorf, Germany

    Hans-Dietrich Röher

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Dietel, M., Niendorf, A. (1990). Cellular Receptors of Hormones and Nonhormone Ligands in Normal and Malignant Cells. In: Beck, L., Grundmann, E., Ackermann, R., Röher, HD. (eds) Hormone-Related Malignant Tumors. Recent Results in Cancer Research, vol 118. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83816-3_1

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