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Characterization of Hodgkin’s Disease Derived Cell Line HDLM-2

  • H. G. Drexler
  • S. M. Gignac
  • A. V. Hoffbrand
  • B. F. Leber
  • J. Norton
  • M. S. Lok
  • J. Minowada
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 117)

Abstract

The origin of the cells which are pathognomonic for Hodgkin’s disease (HD), the Hodgkin (H) and Reed-Sternberg (RS) cells, remains controversial (Drexler et al. 1987; Jones 1987). The analysis of H-RS cells is hampered by the scarcity of the neoplastic cells and contamination with bystander cells. The event of improved tissue culture methodology for the establishment of immortalized cell lines has greatly enhanced the possibilities of studying neoplastic hematopoietic cells. The advantages are the monoclonality of the cell population and the unlimited access to cells which retain their phenotypic characteristics in long-term culture.

Keywords

Immortalize Cell Line Immunoglobulin Heavy Chain Gene Germline Configuration CD15 McAbs Similar Phenotypic Profile 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1989

Authors and Affiliations

  • H. G. Drexler
    • 1
  • S. M. Gignac
    • 1
  • A. V. Hoffbrand
    • 1
  • B. F. Leber
    • 1
  • J. Norton
    • 1
  • M. S. Lok
    • 1
  • J. Minowada
    • 1
  1. 1.Department of HaematologyRoyal Free Hospital, School of MedicineLondonGreat Britain

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