Abstract
With the application of improved methods of cell culture and chromosome banding within the past 10 years, our understanding of the specificity of certain chromosome abnormalities in tumor cells has grown and it has been shown that specific chromosome changes are of diagnostic and prognostic significance. Enormous progress in cancer research has been accomplished by the association of cytogenetic and molecular genetic data leading to the localization of cellular oncogenes and cell differentiation genes in chromosome regions which are nonrandomly involved in marker formation.
The work was supported in part by research grants from the Deutsche Forschungsgemeinschaft (Fo 91/11–1).
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References
Anonymous (1985) Second malignancies in lymphoma patients. Lancet II: 1163–1164 (editorial)
Dean M, Park M, Le Beau MM, Robins TS, Diaz MO, Rowley JD, Blair DG, Vande Woude GF (1985) The human met oncogene is related to the tyrosine kinase oncogenes. Nature 318: 385–388
De Braekeleer M (1986) Cytogenetic studies in secondary leukemia: statistical analysis. Oncology 43: 358–363
Fleischmann T, Krizsa F (1977) Chromosomes in malignant lymphomas. Haematologia Budap 11: 47–55
Fonatsch C, Gradl G (1987) Chromosomenaberrationen und maligne Lymphome. Onkologie 10: 206–216
Fonatsch C, Schaadt M, Kirchner HH, Diehl V (1980) A possible correlation between the degree of karyotype aberrations and the rate of sister chromatid exchanges in lymphoma lines. Int J Cancer 26: 749–756
Fonatsch C, Kirchner HH, Schaadt M, Günzel M, Diehl V (1981) Sister chromatid exchange in lymphoma lines and lymphoblastoid cell lines before and after heterotransplantation into nude mice. Int J Cancer 28: 441–445
Fonatsch C, Diehl V, Schaadt M, Burrichter H, Kirchner HH (1986) Cytogenetic investigations in Hodgkin’s disease: I. Involvement of specific chromosomes in marker formation. Cancer Genet Cytogenet 20: 39–52
Fonatsch C, Gradl G, Ragoussis J, Ziegler A (1987) Assignment of the TCP1 locus to the long arm of human chromosome 6 by in situ hybridization. Cytogenet Cell Genet 45: 109–112
Fukuhara S, Rowley JD (1978) Chromosome 14 translocations in non-Burkitt lymphomas. Int J Cancer 22: 14–21
Gödde-Salz E (1984) Chromosomenaberrationen bei Lymphomen and Lymphom-ähnlichen Erkrankungen. Thieme, Stuttgart
Hossfeld DK, Schmidt CG (1978) Chromosome findings in effusions from patients with Hodgkin’s disease. Int J Cancer 21: 147–156
Human Gene Mapping 9 (1987) Ninth International Workshop on Human Gene Mapping. Frézal J, Klinger HP (eds) Cytogenet Cell Genet 46: 1–4
Jones DB, Scott CS, Wright DH, Stein H, Beverley PCL, Payne SV, Crawford DH (1985) Phenotypic analysis of an established cell line derived from a patient with Hodgkin’s disease ( HD ). Hematol Oncol 3: 133–145
Kamesaki H, Fukuhara S, Tatsumi E, Uchino H, Yamabe H, Miwa H, Shirakawa S, Hatanaka M, Honjo T (1986) Cytochemical, immunologic, chromosomal, and molecular genetic analysis of a novel cell line derived from Hodgkin’s disease. Blood 68: 285–292
Lawler SD, Swansbury GJ (1987) Cytogenetic studies in Hodgkin’s disease. In: Selby P, McElwain TJ (eds) Hodgkin’s disease. Blackwell Scientific, Oxford, pp 43–67
Mitelman F (1985) Catalog of chromosome aberrations in cancer, 2nd edn. Alan R Liss, New York
Pedersen-Bjergaard J, Philip P (1987a) Chromosome characteristics of therapy-related acute non-lymphocytic leukemia and preleukemia: possible implications for pathogenesis of the disease. Leuk Res 11: 315–318
Pedersen-Bjergaard J, Philip P (1987b) Cytogenetic characteristics of therapy-related acute nonlymphocytic leukaemia, preleukaemia and acute myeloproliferative syndrome: correlation with clinical data for 61 consecutive cases. Br J Haematol 66: 199–207
Poppema S, de Jong B, Atmosoerodjo J, Idenburg V, Visser L, de Ley L (1985) Morphologic, immunologic, enzyme histochemical and chromosomal analysis of a cell line derived from Hodgkin’s disease. Cancer 55: 683–690
Reeves BR (1973) Cytogenetics of malignant lymphomas. Studies utilising a Giemsa-banding technique. Hum Genet 20: 231–250
Reeves BR, Pickup VL (1980) The chromosome changes in non-Burkitt lymphomas. Hum Genet 53: 349–355
Watson DK, McWilliams-Smith MJ, Kozak C, Reeves R, Gearhart J, Nunn MF, Nash W, Fowle III JR, Duesberg P, Papas TS, O’Brien SJ (1986) Conserved chromosomal positions of dual domains of the ets protooncogene in cats, mice, and humans. Proc Natl Acad Sci USA 83: 1792–1796
Zech L, Haglund U, Nilsson K, Klein G (1976) Characteristic chromosomal abnormalities in biopsies and lymphoid cell lines from patients with Burkitt and non-Burkitt lymphomas. Int J Cancer 17: 47–56
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Fonatsch, C., Gradl, G., Rademacher, J. (1989). Genetics of Hodgkin’s Lymphoma. In: Diehl, V., Pfreundschuh, M., Loeffler, M. (eds) New Aspects in the Diagnosis and Treatment of Hodgkin’s Disease. Recent Results in Cancer Research, vol 117. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83781-4_4
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DOI: https://doi.org/10.1007/978-3-642-83781-4_4
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