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Current Stanford Clinical Trials for Hodgkin’s Disease

  • R. T. Hoppe
  • S. J. Horning
  • S. L. Hancock
  • S. A. Rosenberg
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 117)

Abstract

Prospective randomized clinical trials for Hodgkin’s disease were initiated at Stanford University by Dr. Henry S. Kaplan and Dr. Saul A. Rosenberg in 1962. In the subsequent 25 years, nearly 1000 patients have been accrued to four generations of clinical trials. In addition, during the same period, a similar number of patients were treated with programs identical to those used on the clinical trials, but were not assigned by randomization (Table 1). Each generation of clinical trials has built strongly upon the experience obtained in the preceding trials and has also incorporated new concepts in Hodgkin’s disease management developed by other investigators. The use of standardized treatment programs among the nonrandomized patients and the careful follow-up of all patients permit evaluation of the entire cohort of nearly 2000 patients for identification of prognostic factors, longterm complications of therapy, etc.

Keywords

Bulky Disease Relapse Risk Combine Modality Therapy Involve Field Irradiation Total Lymphoid Irradiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bonadonna G, Zucali R, Delena M, Valagussa P (1977) Combined chemotherapy ( MOPP or ABVD) - radiotherapy approach in advanced Hodgkin’s disease. Cancer Treat Rep 61: 769–777Google Scholar
  2. Hoppe RT, Portlock CS, Glatstein E, Rosenberg SA, Kaplan HS (1979) Alternating chemotherapy and irradiation in the treatment of advanced Hodgkin’s disease. Cancer 43: 472–481PubMedCrossRefGoogle Scholar
  3. Hoppe RT, Coleman CN, Cox RS, Rosenberg SA, Kaplan HS (1982) The management of stage I-II Hodgkin’s disease with irradiation alone or combined modality therapy: the Stanford experience. Blood 59: 455–465PubMedGoogle Scholar
  4. Hoppe RT, Horning SJ, Rosenberg SA (1985) The concept, evolution, and preliminary results of the current Stanford clinical trials for Hodgkin’s disease. Cancer Sury 4: 459–475Google Scholar
  5. Horning SJ, Hoppe RT, Rosenberg SA (1988) VBM: an effective adjuvant in favorable Hodgkin’s disease. J Clin Oncol 6: 1822–1831PubMedGoogle Scholar
  6. Kaplan HS (1980) Hodgkin’s disease, 2nd edn. Harvard University Press (Cambridge, MA) Rosenberg SA, Kaplan HS (1985) The evolution and summary results of the Stanford randomized clinical trials of the management of Hodgkin’s disease: 1962–1984. Int J Radiat Oncol Biol Phys 11: 5–22Google Scholar
  7. Santoro A, Bonadonna G, Bonfante V, Valagussa P (1982) Alternating drug combinations in the treatment of advanced Hodgkin’s disease. N Engl J Med 306: 770–775PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1989

Authors and Affiliations

  • R. T. Hoppe
    • 1
  • S. J. Horning
    • 1
  • S. L. Hancock
    • 1
  • S. A. Rosenberg
    • 1
  1. 1.Department of Radiation Oncology and Department of Medicine, Division of Medical OncologyStanford UniversityStanfordUSA

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