Transplantation Dopamin-synthetisierender Zellen in das Dopamin-verarmte Striatum beim Parkinson-Syndrom

  • W. H. Oertel
  • A. Fine
  • S. P. Hunt
  • M. Nomoto
  • P. N. Chong
  • J. A. Temlett
  • P. Jenner
  • C. D. Marsden
Part of the Verhandlungen der Deutschen Gesellschaft für Neurologie book series (VDGNEUROLOGIE, volume 5)

Zusammenfassung

Die Parkinson-Erkrankung geht mit einer Degeneration von dopaminergen mesenzephalostriatalen Neuronen einher. Amantadine, Anticholinergika, der Dopaminvorläufer L-DOPA, Dopaminagonisten und Monoamino-Oxidase-B-Hemmer werden in der medikamentösen Behandlung der Parkinson-Erkrankung eingesetzt. Nach etwa 3–7 Jahren zeigen sich jedoch in der Regel Schwierigkeiten im Rahmen der medikamentösen Langzeittherapie, wie Wirkungsfluktuationen von L-DOPA, Dyskinesien und, wenn auch seltener, psychotische Phänomene [32]. Auf Grund dieser Probleme werden andere Therapieformen für die Parkinson-Krankheit gesucht.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • W. H. Oertel
  • A. Fine
  • S. P. Hunt
  • M. Nomoto
  • P. N. Chong
  • J. A. Temlett
  • P. Jenner
  • C. D. Marsden

There are no affiliations available

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