Skip to main content
SpringerLink
Log in

Transplantation Dopamin-synthetisierender Zellen in das Dopamin-verarmte Striatum beim Parkinson-Syndrom

  • Chapter
Verhandlungen der Deutschen Gesellschaft für Neurologie

Part of the book series: Verhandlungen der Deutschen Gesellschaft für Neurologie ((VDGNEUROLOGIE,volume 5))

  • 9 Accesses

Zusammenfassung

Die Parkinson-Erkrankung geht mit einer Degeneration von dopaminergen mesenzephalostriatalen Neuronen einher. Amantadine, Anticholinergika, der Dopaminvorläufer L-DOPA, Dopaminagonisten und Monoamino-Oxidase-B-Hemmer werden in der medikamentösen Behandlung der Parkinson-Erkrankung eingesetzt. Nach etwa 3–7 Jahren zeigen sich jedoch in der Regel Schwierigkeiten im Rahmen der medikamentösen Langzeittherapie, wie Wirkungsfluktuationen von L-DOPA, Dyskinesien und, wenn auch seltener, psychotische Phänomene [32]. Auf Grund dieser Probleme werden andere Therapieformen für die Parkinson-Krankheit gesucht.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Backlund E-O, Granberg PO, Hamberger B et al. (1985) Transplantation of adrenal medullary tissue to striatum in parkinsonism. J Neurosurg 62: 169–173

    Article  PubMed  CAS  Google Scholar 

  2. Bankiewicz KS, Plunkett RJ, Oldfield EH et al. (1988) Transient and long term functional improvement by adrenal and fetal mesencephalic implants into caudate nuclei of MPTP parkinsonian monkeys. In: Gash DM, Sladek JR jr (eds) Transplantation into the mammalian CNS: Preclinical and clinical studies. Prog Brain Res 78: 543–549

    Google Scholar 

  3. Björklund A, Lindvall O, Isacson O et al. (1987) Mechanisms of action of intracerebral neural implants: Studies on nigral and striatal grafts to the lesioned striatum. Trends Neurosci 10: 505–516

    Article  Google Scholar 

  4. Bohn MC, Cupit L, Marciano F, Gash DM (1987) Adrenal medulla grafts enhance recovery of striatal dopaminergic fibers. Science 237: 913–916

    Article  PubMed  CAS  Google Scholar 

  5. Brundin P, Strecker RE, Widner H et al. (1988) Human fetal dopamine neurons grafted in a rat model of Parkinson’s disease: Immunological aspects, spontaneous and drug-induced behaviour, and dopamine release. Exp Brain Res 70: 192–208

    PubMed  CAS  Google Scholar 

  6. Burns RS, Chiueh CC, Markey SP, Ebert MH, Jacobowitz DM, Kopin IJ (1983) A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-l,2,3,6-tetrahydropyridine. Proc Natl Acad Sci USA 80: 4546–4550

    Article  PubMed  CAS  Google Scholar 

  7. Burns RS, Allen RS, Tulipan NB (1988) Adrenal medullary transplants to caudate nucleus in Parkinson’s disease. Neurology 38[Suppl 1]: 143

    Google Scholar 

  8. Burns RS (1988) Persönliche Mitteilung

    Google Scholar 

  9. Carmichael SW, Wilson RJ, Brimijoin WS et al. (1988) Decreased catecholamines in the adrenal medulla of patients with Parkinsonism. N Engl J Med 318: 254

    PubMed  CAS  Google Scholar 

  10. Carvey PM, Kroin JS, Zhang TJ et al. (1988) Biochemical and immunochemical characterization of ventricular CSF from Parkinson’s disease (PD) patients with adrenal medulla transplants in the patients. Neurology 38[Suppl 1]: 144

    Google Scholar 

  11. Den Hartog Jager WA (1970) Histochemistry of adrenal bodies in Parkinson’s disease. Arch Neurol 23: 528–533

    Article  Google Scholar 

  12. Drucker-Colin R, Madrazo I, Ostrosky-Solis F, Shkurovich M, Franco R, Torres C (1988) Adrenal medullary tissue transplants in the caudate nucleus of Parkinson patients. In: Gash DM, Sladek JR jr (eds) Transplantation into the mammalian CNS: Preclinical and clinical studies. Prog Brain Res 78: 567–574

    Google Scholar 

  13. Fine A, Hunt, Oertel WH S et al. (1988) Transplantation of embryonic marmoset dopaminergic neurons to the corpus striatum of marmosets rendered parkinsonian by MPTP. In: Gash DM, Sladek JR jr (eds) Transplantation into the mammalian CNS: Preclinical and clinical studies. Prog Brain Res 78: 479–489

    Google Scholar 

  14. Freed WJ, Morihisa JM, Spoor E, Hoffer BJ, Olson L, Seiger A, Wyatt RJ (1981) Transplanted adrenal cromaffin cells in rat brain reduce lesion-induced rotational behavior. Nature 292: 351–352

    Article  PubMed  CAS  Google Scholar 

  15. Freed WJ, Cannon-Spoor H, Krauthammer E (1986) Intrastriatal adrenal medulla grafts in rats. Long-term survival and behavioral effects. J Neurosurg 65: 664–670

    Article  PubMed  CAS  Google Scholar 

  16. Freed WJ, Cannon-Spoor HE (1988) Cortical lesions increase reinnervation of the dorsal striatum by substantia nigra grafts. Brain Res 446: 133–143

    Article  PubMed  CAS  Google Scholar 

  17. Gage FH, Wolff JA, Rosenberg MB, Xu L, Yee L-K, Shults C, Friedmann T (1987) Grafting genetically modified cells to the brain: Possibilities for the future. Neuroscience 23: 795–807

    Article  PubMed  CAS  Google Scholar 

  18. Gash DM, Notter MFD, Okawara SH, Kraus AL, Joynt RJ (1987) Amitotic neuroblastoma cells used for neural implants in monkeys. Science 233: 1420–1422

    Article  Google Scholar 

  19. Goetz CG, Tanner CM, Penn RD, Shannon KM, Klawans HL (1988) Efficacy of intrastriatal adrenal medulla transplant in Parkinson’s disease. Neurology 38[Suppl 1]: 142

    Google Scholar 

  20. Hefti F, Hartikka J, Schlumpf M (1985) Implantation of PC 12 cells into the corpus striatum of rats with lesions of the dopaminergic nigrostriatal neurons. Brain Res 348: 283–288

    Article  PubMed  CAS  Google Scholar 

  21. Hitchcock ER, Clough C, Hughes R, Kenny B (1988) Embryos and Parkinson’s disease. Lancet 1: 1274

    Article  PubMed  CAS  Google Scholar 

  22. Hurtig HI, Trojanowski JQ, Joyce J, Sladek JR jr, Goldstein M (1988) Adrenal medulla autograft to caudate nucleus for treatment of Parkinson’s disease: Post mortem analysis of a case. Proc. 9th Internat. Symp. Parkinson’s disease, June 5-9, Israel, p 72

    Google Scholar 

  23. Jellinger K (1986) Overview of morphologic changes in Parkinson’s disease. In: Yahr MD, Bergmann KJ (eds) Parkinson’s disease. Adv Neurol 45: 1–18

    Google Scholar 

  24. Jellinger K (1988) Persönliche Mitteilung

    Google Scholar 

  25. Kish SJ, Shannak K, Hornykiewicz O (1988) Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson’s disease. N Engl J Med 318: 876–880

    Article  PubMed  CAS  Google Scholar 

  26. Langsten JW, Ballard P, Tetrud JW, Irwin I (1983) Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219: 979–980

    Article  Google Scholar 

  27. Lindvall O, Backlund E-O, Farde L et al. (1987) Transplantation in Parkinson’s disease: Two cases of adrenal medullary grafts to the putamen. Ann Neurol 22: 457–468

    Article  PubMed  CAS  Google Scholar 

  28. Lindvall O (1988) Persönliche Mitteilung

    Google Scholar 

  29. Madrazo I, Drucker-Colin R, Diaz V, Martinez-Mata J, Torres C, Becerril JJ (1987) Open microsurgical autograft of adrenal medulla to the right caudate nucleus in two patients with intractable Parkinson’s disease. N Engl J Med 316: 831–834

    Article  PubMed  CAS  Google Scholar 

  30. Madrazo I, Leon V, Torres C (1988) Transplantation of fetal substantia nigra and adrenal medulla to the caudate nucleus in two patients with Parkinson’s disease. N Engl J Med 318: 51

    PubMed  CAS  Google Scholar 

  31. Morihisa JM, Nakamura RK, Freed WJ, Mishkin M, Wyatt RJ (1984) Adrenal medulla grafts survive and exhibit catecholamine-specific fluorescence in the primate brain. Exp Neurol 84: 643–653

    Article  PubMed  CAS  Google Scholar 

  32. Oertel WH (1987) Parkinson-Syndrom und andere Erkrankungen der Basalganglien (EPMS-Erkrankungen). In: Elger CE, Dengler R (Hrsg) Jahrbuch der Neurologie 1987. Wissenschaftliche Verlagsgesellschaft Regensberg & Biermann, Münster, S 91–103

    Google Scholar 

  33. Oertel WH (1988) Transplantation von Dopamin-synthetisierenden Zellen — eine neue Therapie der Parkinson-Krankheit? Aktuel Neurol 15: 156–160

    Article  Google Scholar 

  34. Oertel WH, Gasser T (1989) Ist die Transplantation von Dopamin-synthetisierenden Zellen eine neue Behandlung der Parkinson-Krankheit? In: Elger CE, Dengler R (Hrsg) Jahrbuch der Neurologie 1988. Wissenschaftliche Verlagsgesellschaft Regensberg & Biermann, Münster, S 13–26

    Google Scholar 

  35. Olanow CW, Cahill D, Cox C (1988) Autologous transplantation of adrenal medulla to caudate nucleus in Parkinson’s disease. Neurology 38[Suppl 1]: 142

    Google Scholar 

  36. Olson L, Backlund E-O, Gerhardt G et al. (1986) Nigral and adrenal grafts in Parkinsonism: Recent basic and clinical studies. In: Yahr MD, Bergmann KJ (eds) Parkinson’s disease. Adv Neurol 45: 85–94

    Google Scholar 

  37. Peterson DI, Price ML, Small CS, Linda L (1988) Autopsy findings in a patient that had an adrenal-to-brain transplant for Parkinson’s disease. Neurology 38[Suppl 1]: 144

    Google Scholar 

  38. Redmond DE, Sladek JR jr, Roth RH, Collier TJ, Elsworth JD, Deutch AY, Haber S (1986) Fetal neuronal grafts in monkeys given methylphenyltetrahydropyridine. Lancet 1: 1125–1127

    Article  PubMed  CAS  Google Scholar 

  39. Riederer P, Rausch WD, Birkmayer W, Jellinger K, Seemann D (1978) CNS modulation of adrenal tyrosine hydroxylase in Parkinson’s disease and metabolic encephalopathies. J Neural Transm [Suppl] 14: 121

    CAS  Google Scholar 

  40. Robertson JT (1988) Persönliche Mitteilung

    Google Scholar 

  41. Sladek JR jr, Redmond DE jr, Collier TJ et al. (1988) Long term reversal of MPTP-induced Parkinsonism in primates with fetal dopamine nerve cell transplants. Reverses MPTP-induced parkinsonism. In: Gash DM, Sladek JR jr (eds) Transplantation into the mammalian CNS: Pre-clinical and clinical studies. Prog Brain Res 78: 497–506

    Google Scholar 

  42. Sladek JR jr, Shoulson I (1988) Neural transplantation: A call for patience rather than patients. Science 240: 1386–1388

    Article  PubMed  Google Scholar 

  43. Tanner CM, Goetz CG, Gilley DW et al.(1988) Behavioral aspects of intrastriatal adrenal medulla transplant surgery in Parkinson’s disease (PD). Neurology 38[Suppl 1]: 143

    Google Scholar 

  44. Thoenen H, Barde YA, Davies AM, Johnson JE (1987) Neurotrophic factors and neuronal death. Ciba Foundat Symp 126: 82–95

    CAS  Google Scholar 

  45. Walters L (1988) Ethical issues in fetal research: A look back and a look forward. Clin Res 36: 209–214

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. W. H. Oertel
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Fine
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. P. Hunt
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Nomoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. N. Chong
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. A. Temlett
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. P. Jenner
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. C. D. Marsden
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Zentrum der Neurologie und Neurochirurgie, Abteilung für Neurologie, Klinikum der Universität Frankfurt, Schleusenweg 2-16, D-6000, Frankfurt/Main 71, Germany

    Peter-Alexander Fischer , Horst Baas  & Wolfgang Enzensberger ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Oertel, W.H. et al. (1989). Transplantation Dopamin-synthetisierender Zellen in das Dopamin-verarmte Striatum beim Parkinson-Syndrom. In: Fischer, PA., Baas, H., Enzensberger, W. (eds) Verhandlungen der Deutschen Gesellschaft für Neurologie. Verhandlungen der Deutschen Gesellschaft für Neurologie, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83771-5_26

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-83771-5_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51091-8

  • Online ISBN: 978-3-642-83771-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation