Radiobiology in Radiation Therapy

  • Jürgen Kiefer


Radiobiological experience may influence radiotherapeutical practice and lead to new modalities. The treatment of the topic can only be exemplary in nature and cannot be comprehensive. Phototherapy is mainly applied with certain nonmalignant skin diseases but it is recently extended also to non-skin cancers. Ionizing radiation is widely used in cancer treatment. Experimental model systems are described which were designed to understand the underlying principles and to test possible new developments. A few such examples are discussed: namely new types of radiation, particularly those with better depth dose distributions, the combination with hyperthermia or the concomitant application of chemical agents.


Relative Biological Effectiveness Biologically Effective Dose Radiation Type Radiation Biology Oxygen Effect 
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Further reading

  1. ANDREONI and CUBEDOU 1984, GOMER 1987, PARRISH et al. 1978, VAN DER LEUN and WEELDEN 1984Google Scholar
  2. BARENDSEN 1982, DALRYMPLE et al. 1973, DUNCAN and NIAS 1977, ELLIS 1968, FOWLER 1984, ORTON 1986a, ORTON and COHEN 1988, SUTHERLAND and DURAND 1976, SUTHERLAND 1988, STEEL 1977, WITHERS 1975, WITHERS et al. 1982Google Scholar
  3. ABE and HIROAKA 1985, ADAMS, FOWLER and WARDMAN 1978, BELLAMY and HILL 1984, BLAKELY et al. 1984, CASTRO et al. 1983, 1987, DIETZEL 1978, FIELD 1976, GOODMAN 1987, HAHN 1978, 1982, HAR-KEDAR and BLEEHEN 1976, MUNZENRIDER et al. 1987, RAJU 1980, STEEL 1977, STREFFER et al. 1978, SAUNDERS et al. 1986, TSUNEMOTO et al. 1987, TUBIANA 1987, VAETH 1969Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • Jürgen Kiefer
    • 1
  1. 1.StrahlenzentrumJustus-Liebig-UniversitätGießenDeutschland

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