Skip to main content

Natural History of Viral Myocarditis: Critical Viewpoints

  • Conference paper
Advances in Cardiomyopathies

Abstract

Viral myocarditis is regarded as the most important element in the development of dilated cardiomyopathy (DCM) [1–4]. Also, our analysis of biopsy samples from the myocardium [5–22] in patients with idiopathic DCM and with arrythmias and/or conduction disturbance of an idiopathic nature showed findings highly suggestive of myocarditis in 15% of the DCM cases and in 8.7% of the cases with arrythmias and/or conduction disturbances [17].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Sekiguchi M, Olsen EGJ, Goodwin JF (eds) (1985) Myocarditis and related disorders. Heart Vessels Suppl 1

    Google Scholar 

  2. Kawai C, Abelmann WH (eds) (1987) Pathogenesis of myocarditis and cardiomyopathy. Recent experimental and clinical studies. University of Tokyo Press, Tokyo

    Google Scholar 

  3. Maisch B (ed) (1987) Inflammatory heart disease. Eur Heart J 8 [Suppl J]

    Google Scholar 

  4. Schultheiss H-P (ed) (1988) New concepts in viral heart disease: virology, immunology and clinical management. Springer, Berlin Heidelberg New York

    Google Scholar 

  5. Sekiguchi M, Hiroe M, Ogasawara S, Nishikawa T (1981) Practical aspects of endomyocardial biopsy. Ann Acad Med Singapore 10 (Suppl): 115–128

    PubMed  CAS  Google Scholar 

  6. Sekiguchi M, Hiroe M, Take M, Hirosawa K (1980) Clinical and histopathological profile of sarcoidosis of the heart and acute myocarditis; II. Myocarditis. Jpn Circul J 44: 264–273

    Article  CAS  Google Scholar 

  7. Sekiguchi M, Hiroe M, Take M, Akamatsu T, Takahashi S (1980) Vasodilator therapy in congestive cardiomyopathy and myocarditis. In: Sekiguchi M, Olsen EGJ (eds) Cardio-myopathy, clinical, pathological and theoretical aspects. University of Tokyo Press, Tokyo and University Park Press, Baltimore, pp 257–275

    Google Scholar 

  8. Take M, Sekiguchi M, Hiroe M, Hirosawa K (1981) Early clinical profiles of histopatho- logically proven cases with acute idiopathic myocarditis and a proposal for diagnostic criteria. Jpn Circul J 45: 1415–1420

    Article  CAS  Google Scholar 

  9. Take M, Sekiguchi M, Hiroe M, Hirosawa K (1982) Long-term follow-up of electrocardiographic findings in patients with acute myocarditis proven by endomyocardial biopsy. Jpn Circul J 46: 1127–1234

    Article  Google Scholar 

  10. Hasumi M, Sekiguchi M, Morimoto S, Take M, Hirosawa K (1983) Ventriculographic findings at the convalescent stage in eleven cases with acute myocarditis. Jpn Circul J 47: 1310–1316

    Article  CAS  Google Scholar 

  11. Yu Z-X, Sekiguchi M, Hiroe M, Take M, Hirosawa K (1984) Histopathological findings of acute and convalescent myocarditis obtained by serial endomyocardial biopsy. Jpn Circul J 48: 1368–1374

    Article  CAS  Google Scholar 

  12. Hiroe M, Sekiguchi M, Take M, Matsuda M, Hirosawa K (1985) Hemodynamic studies and response to a combined therapy of nitroglycerin ointment and dopamine in patients with acute myocarditis. Heart Vessels Suppl 1: 180–186

    Article  PubMed  CAS  Google Scholar 

  13. Hiroe M, Sekiguchi M, Take M, Kusakabe K, Shigeta A, Hirosawa K (1985) Long follow-up study in patients with prior myocarditis by radionuclide methods. Heart Vessels Suppl 1: 199–203

    Article  PubMed  CAS  Google Scholar 

  14. Sekiguchi M, Hiroe M, Yu Z-X, Hasumi M (1987) A serial endomyocardial biopsy study on myocarditis. In: Kawai C, Abelmann WH (eds) Pathogenesis of myocarditis and cardiomyopathy. Recent experimental and clinical studies. University of Tokyo Press, Tokyo, pp 213–231

    Google Scholar 

  15. Sekiguchi M, Yu Z-X, Hasumi M, Hiroe M, Morimoto S, Nishikawa T (1985) Histopathologic and ultrastructural observations of acute and convalescent myocarditis. A serial endomyocardial biopsy study. Heart Vessels Suppl 1: 143–153

    Article  PubMed  CAS  Google Scholar 

  16. Sekiguchi M, Olsen EGJ, Goodwin JF (1985) Editor’s comments on the biopsy diagnosis of myocarditis. Heart Vessels Suppl 1: 306–308

    Article  Google Scholar 

  17. Take M, Sekiguchi M, Hiroe M, Hirosawa K (1985) A clinicopathologic study on a cause of idiopathic cardiomyopathy and arrythmia and conduction disturbance employing endomyocardial biopsy. Heart Vessels Suppl 1: 159–164

    Article  PubMed  CAS  Google Scholar 

  18. Yu Z-X, Sekiguchi M, Hiroe M, Take M, Hirosawa K (1985) A comparative ultrastructural study on the nature of interstitial cell constituents in idiopathic myocarditis and myocardial infarction. Heart Vessels Suppl 1: 154–158

    Article  PubMed  CAS  Google Scholar 

  19. Yu Z-X, Sekiguchi M, Hiroe M, Hasumi M, Morimoto S, Hirosawa K (1985) On the interstitial fibrotic changes in acute and convalescent myoarditis obtained by serial endomyocardial biopsy. Jpn Circuí J 49: 1270–1276

    Article  CAS  Google Scholar 

  20. Hasumi M, Sekiguchi M, Yu Z-X, Hirosawa K, Hiroe M (1986) Analysis of histopathologic findings in cases with dilated cardiomyopathy with special reference to formulating diagnostic criteria on the possibility of postmyocarditic change. Jpn Circuí J 50: 1280–1287

    Article  CAS  Google Scholar 

  21. Sekiguchi M, Hiroe M, Hiramitsu S, Izumi T (1988) Natural history of acute viral or idiopathic myocarditis: a clinical and endomyocardial biopsy follow-up. In: Schultheiss H-P (ed) New concepts in viral heart disease: virology, immunology and clinical management. Springer, Berlin Heidelberg New York Tokyo, pp 33–50

    Chapter  Google Scholar 

  22. Sekiguchi M, Hiroe M, Yu Z-X, Hasumi M (1986) Observer variation study in myocarditis using ROC analysis. Presented at the XII Congress of Cardiology, Washington

    Google Scholar 

  23. Mason JW, Billingham ME, Ricci DR (1980) Treatment of acute inflammatory myocarditis assisted by endomyocardial biopsy. Am J Cardiol 45: 1037–1044

    Article  PubMed  CAS  Google Scholar 

  24. Olsen EGJ (1985) Histopathologic aspects of viral myocarditis and its diagnostic criteria. Heart Vessels Suppl 1: 130–132

    Article  PubMed  CAS  Google Scholar 

  25. Billingham ME (1985) The diagnostic criteria of myocarditis by endomyocardial biopsy. Heart Vessel Suppl 1: 133–137

    Article  CAS  Google Scholar 

  26. Kawai C (1988) Clinical and experimental aspects of treatment for viral myocarditis. In: Schultheiss H-P (ed) New concepts in viral heart disease: virology, immunology and clinical management. Springer, Berlin Heidelberg New York Tokyo, pp 433–437

    Chapter  Google Scholar 

  27. Kawamura K, Kitaura Y, Morita H, Deguchi H, Kotaka M (1985) Viral and idiopathic myocarditis in Japan: a questionnaire survey. Heart Vessels Suppl 1: 18–22

    Article  PubMed  CAS  Google Scholar 

  28. Kawamura K (1987) Report of a committee on myocarditis. Annual Report for Intractable Disease. Ministry of Health and Welfare of Japan, p13 (in Japanese)

    Google Scholar 

  29. Shanes JG, Ghali J, Billingham ME, Ferrans VJ, Fenoglio JJ, Edwards WD, Tsai CC, Saffitz JE, Isner J, Furner S, Subramanian R (1987) Interobserver variability in the pathologic interpretation of endomyocardial biopsy results. Circulation 75: 401–405

    Article  PubMed  CAS  Google Scholar 

  30. Fenoglio JJ, Ursell PC, Kelogg CF, Pil M, Drusin RE, Weiss MB (1983) Diagnosis and classification of myocarditis by endomyocardial biopsy. N Engl J Med 308: 12–18

    Article  PubMed  Google Scholar 

  31. Edwards WD, Holmes DR Jr, Reeder GS (1982) Diagnosis of active lymphocytic myocarditis by endomyocardial biopsy: quantitative criteria for light microscopy. Mayo Clin Proc 57: 419–25

    PubMed  CAS  Google Scholar 

  32. Archard LC, Bowles NE, Freeke C, Meany B, Morgan-Capner P, Olsen EGJ, Richardson PJ (1988) Enterovirus RNA in myocarditis. Eur Heart J Suppl 1: 19 (abstract)

    Google Scholar 

  33. Kilbourne E, Wilson CB, Perrier D (1956) The induction of gross myocardial lesions by a coxsackie (pleurodynia) virus and cortisone. J Clin Invest 35: 362–370

    Article  PubMed  CAS  Google Scholar 

  34. Tomioka N, Kishimoto C, Matsumori A, Kawai C (1986) Effects of prednisolone on acute viral myocarditis in mice. J Am Coll Cardiol 7: 868–872

    Article  PubMed  CAS  Google Scholar 

  35. Hosenpud JD, McAnulty JH, Nlies NR (1985) Lack of objective improvement in ventricular systolic function in patients with myocarditis treated with azathioprine and predon- isone. J Am Coll Cardiol 6: 797–801

    Article  PubMed  CAS  Google Scholar 

  36. Salvi A, Hrovatin E, Dreas L, Silvestri F, Camerini F (1987) Changes in histology and left ventricular ejection fraction during immunosuppressive treatment in active myocarditis. Eur Heart J 8 (Suppl J): 267–269

    Google Scholar 

  37. Quigley PJ, Richardson PJ, Meany BT, Olsen EG J, Monaghan MJ, Jackson G, Jewitt DE (1987) Long-term follow-up of acute myocarditis. Correlation of ventricular function and outcome. Eur Heart J 8 (Suppl J): 39–42

    Google Scholar 

  38. Maisch B, Deeg P, Liebau G, Kochsick K (1983) Diagnostic relevance of humoral and cytotoxic immune reactions in primary and secondary dilated cardiomyopathy. Am J Cardiol 52: 1072–1078

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Sekiguchi, M., Hiroe, M., Nunoda, S., Hongo, M., Misawa, T. (1990). Natural History of Viral Myocarditis: Critical Viewpoints. In: Baroldi, G., Camerini, F., Goodwin, J.F. (eds) Advances in Cardiomyopathies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83760-9_30

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-83760-9_30

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83762-3

  • Online ISBN: 978-3-642-83760-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics