Abstract
An association between enterovirus infection of myocardium and heart muscle disease has been established by the use of virus-specific molecular hybridisation probes under circumstances where the isolation of infectious virus or the immunocytochemical demonstration of virus antigens is generally not possible [3]. It is widely accepted that enteroviruses are major aetiological agents of inflammatory heart muscle disease [6, 7], and we have detected enteroviral RNA in endomyocardial biopsy samples from six of ten histologically proven cases of acute myocarditis [2]. However, patients are rarely biopsied at this early stage, and we have been concerned with the persistence of enteroviral RNA in myocardium in the progression from healing myocarditis to so-called idiopathic dilated cardiomyopathy [1] and even end-stage disease requiring cardiac transplantation [3].
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References
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Archard, L.C. et al. (1990). Enterovirus RNA Sequences in Hearts with Dilated Cardiomyopathy: A Pathogenetic Link Between Virus Infection and Dilated Cardiomyopathy. In: Baroldi, G., Camerini, F., Goodwin, J.F. (eds) Advances in Cardiomyopathies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83760-9_20
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DOI: https://doi.org/10.1007/978-3-642-83760-9_20
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