Enterovirus RNA Sequences in Hearts with Dilated Cardiomyopathy: A Pathogenetic Link Between Virus Infection and Dilated Cardiomyopathy
An association between enterovirus infection of myocardium and heart muscle disease has been established by the use of virus-specific molecular hybridisation probes under circumstances where the isolation of infectious virus or the immunocytochemical demonstration of virus antigens is generally not possible . It is widely accepted that enteroviruses are major aetiological agents of inflammatory heart muscle disease [6, 7], and we have detected enteroviral RNA in endomyocardial biopsy samples from six of ten histologically proven cases of acute myocarditis . However, patients are rarely biopsied at this early stage, and we have been concerned with the persistence of enteroviral RNA in myocardium in the progression from healing myocarditis to so-called idiopathic dilated cardiomyopathy  and even end-stage disease requiring cardiac transplantation .
KeywordsDilate Cardiomyopathy Virus Persistence Acute Myocarditis Enterovirus Infection Heart Muscle Disease
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