Evolution of Left Ventricular Hypertrophy in Patients with Hypertrophic Cardiomyopathy
Application of echocardiography to cardiac diagnosis in the 1970s represented a major advance in the non-invasive identification of patients with hypertrophic cardiomyopathy (HCM) [1, 2]. Subsequently, the utilization of two-dimensional echocardiography and other ultrasound modalities in large numbers of patients with HCM over many years have stimulated continued definition of the diverse morphologic expression of the disease, changes in left ventricular morphology which appear to be part of its natural history, and the clinical relevance of left ventricular hypertrophy within the broad spectrum of patients [3–18]. As a result, it has become apparent that the morphology of HCM may not be identical or even similar in different phases of life. With these considerations in mind, the present review is focused on the patterns of left ventricular hypertrophy and the relationship between age and left ventricular anatomy in patients with HCM.
KeywordsFatigue Depression Ischemia Radionuclide Cardiomyopathy
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- 19.Maron BJ, Epstein SE (1980) Hypertrophic cardiomyopathy. Recent observations regarding the specificity of three hallmarks of the disease: asymmetric septal hypertrophy, septal disorganization and systolic anterior motion of the anterior mitral leaflet. Am J Cardiol 45: 141–154PubMedCrossRefGoogle Scholar
- 20.Lewis JF, Maron BJ (1989) Diversity of patterns of left ventricular wall thickening in patients with systemic hypertension and marked hypertrophy. Am J Cardiol (in press)Google Scholar
- 25.Spirito P, Maron BJ (1989) Relation between extent of left ventricular hypertrophy and occurrence of sudden cardiac death in hypertrophic cardiomyopathy. J Am Coll Cardiol (in press)Google Scholar
- 30.Spirito P, Maron BJ (1989) Relation between extent of left ventricular hypertrophy and diastolic abnormalities in patients with hypertrophic cardiomyopathy (submitted)Google Scholar