Abstract
IgA deficiency (IgA-D) and common variable immunodeficiency (CVID) are heritable disorders both of which feature an arrest in B cell differentiation. IgA-D is characterized by a normal number of immature IgA-bearing B cells which fail to undergo differentiation into IgA-secreting plasma cells (Conley and Cooper 1981). Similarly, CVID usually features a normal number of B cells, exhibiting a normal distribution of Ig isotypes, which fail to undergo terminal differentiation into antibody-secreting plasma cells (Cooper et al. 1971; Preud’Homme et al. 1973). The causes for the B cell differentiation arrests in IgA-D and CVID are not understood.
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Schaffer, F.M., Palermos, J., Zhu, Z.B., Barger, B.O., Cooper, M.D., Volanakis, J.E. (1989). Genotypic Studies of MHC Class III Genes in Individuals with IgA Deficiency and Common Variable Immunodeficiency. In: Melchers, F., et al. Progress in Immunology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83755-5_72
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DOI: https://doi.org/10.1007/978-3-642-83755-5_72
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