Genotypic Studies of MHC Class III Genes in Individuals with IgA Deficiency and Common Variable Immunodeficiency
IgA deficiency (IgA-D) and common variable immunodeficiency (CVID) are heritable disorders both of which feature an arrest in B cell differentiation. IgA-D is characterized by a normal number of immature IgA-bearing B cells which fail to undergo differentiation into IgA-secreting plasma cells (Conley and Cooper 1981). Similarly, CVID usually features a normal number of B cells, exhibiting a normal distribution of Ig isotypes, which fail to undergo terminal differentiation into antibody-secreting plasma cells (Cooper et al. 1971; Preud’Homme et al. 1973). The causes for the B cell differentiation arrests in IgA-D and CVID are not understood.
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