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Genotypic Studies of MHC Class III Genes in Individuals with IgA Deficiency and Common Variable Immunodeficiency

  • F. M. Schaffer
  • J. Palermos
  • Z. B. Zhu
  • B. O. Barger
  • M. D. Cooper
  • J. E. Volanakis
Conference paper

Abstract

IgA deficiency (IgA-D) and common variable immunodeficiency (CVID) are heritable disorders both of which feature an arrest in B cell differentiation. IgA-D is characterized by a normal number of immature IgA-bearing B cells which fail to undergo differentiation into IgA-secreting plasma cells (Conley and Cooper 1981). Similarly, CVID usually features a normal number of B cells, exhibiting a normal distribution of Ig isotypes, which fail to undergo terminal differentiation into antibody-secreting plasma cells (Cooper et al. 1971; Preud’Homme et al. 1973). The causes for the B cell differentiation arrests in IgA-D and CVID are not understood.

Keywords

Major Histocompatibility Complex Major Histocompatibility Complex Class Common Variable Immunodeficiency CVID Patient Major Histocompatibility Complex Haplotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • F. M. Schaffer
  • J. Palermos
  • Z. B. Zhu
  • B. O. Barger
  • M. D. Cooper
  • J. E. Volanakis

There are no affiliations available

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