The Development of B-Lymphomas in the Chicken
A few years ago, only a single B-cell tumor was known to develop in the chicken. Avian leukosis virus (ALV) induced a bursal-dependent B-lymphoma. The tumor appeared in 4 to 6 month old birds that had been infected on the day of hatch with ALV. We have recently described the development of two other B-cell lymphomas in the chicken. Their biological features and the molecular nature of the initial oncogenic events indicate that these tumors are distinct from each other and from the ALV-induced bursal-dependent lymphoma. It appears that the three tumors develop using different genetic pathways. In this report, I will discuss the biological differences between these tumors.
KeywordsPreneoplastic Lesion Avian Leukosis Virus Reticuloendotheliosis Virus Aile Gene Light Chain Rearrangement
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