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Assembly of the T Cell Receptor/CD3 Complex

  • C. Terhorst
  • B. Alarcon
  • B. Berkhout
  • R. Blumberg
  • H. Clevers
  • K. Georgopoulos
  • C. Hall
  • S. Ley
  • J. Sancho
  • J. Versteegen
  • Th. Wileman
Conference paper

Abstract

The human T cell receptor for antigens is a multichain cell surface receptor consisting of variable (TCR -α/β or TCR -γ/δ and constant elements (CD3 — γ δεζThe exquisite specificity for antigen plus MHC (or CD1) resides in the variable regions of the TCR α/β (or TCR — γ /δ) glycoproteins (1, 2, 3). Since T cell receptors and MHC products (4) (or CD1 glycoproteins (5)) are anchored in the plasma membrane of T lymphocytes and antigen presenting cells, respectively, antigen recognition takes place on the interface between the two cells. A localized and TCR-independent set of adhesion events provides a stablizing environment for the subtle ternary interaction which is dependent upon the fine specificity of its participants. Thus, antigen recognition by T cells is a carefully orchestrated and tightly regulated event.

Keywords

Polypeptide Chain Antigen Recognition Exquisite Specificity Pentameric Complex Nuclear Regulatory Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • C. Terhorst
  • B. Alarcon
  • B. Berkhout
  • R. Blumberg
  • H. Clevers
  • K. Georgopoulos
  • C. Hall
  • S. Ley
  • J. Sancho
  • J. Versteegen
  • Th. Wileman

There are no affiliations available

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