Assembly of the T Cell Receptor/CD3 Complex

  • C. Terhorst
  • B. Alarcon
  • B. Berkhout
  • R. Blumberg
  • H. Clevers
  • K. Georgopoulos
  • C. Hall
  • S. Ley
  • J. Sancho
  • J. Versteegen
  • Th. Wileman
Conference paper

Abstract

The human T cell receptor for antigens is a multichain cell surface receptor consisting of variable (TCR -α/β or TCR -γ/δ and constant elements (CD3 — γ δεζThe exquisite specificity for antigen plus MHC (or CD1) resides in the variable regions of the TCR α/β (or TCR — γ /δ) glycoproteins (1, 2, 3). Since T cell receptors and MHC products (4) (or CD1 glycoproteins (5)) are anchored in the plasma membrane of T lymphocytes and antigen presenting cells, respectively, antigen recognition takes place on the interface between the two cells. A localized and TCR-independent set of adhesion events provides a stablizing environment for the subtle ternary interaction which is dependent upon the fine specificity of its participants. Thus, antigen recognition by T cells is a carefully orchestrated and tightly regulated event.

Keywords

Migration Glycine Polypeptide Half Life Disulfide 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • C. Terhorst
  • B. Alarcon
  • B. Berkhout
  • R. Blumberg
  • H. Clevers
  • K. Georgopoulos
  • C. Hall
  • S. Ley
  • J. Sancho
  • J. Versteegen
  • Th. Wileman

There are no affiliations available

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