The Production and Selection of Memory B Cells in Follicles
The recruitment of virgin B cells into responses to T cell-dependent antigens has been found to be restricted to periods immediately following antigen administration. The established phase of these responses, on the other hand, is maintained by activation of persistent memory B cell clones (Gray et al. 1986, MacLennan and Gray 1986). Memory B cell clones which come to dominate T cell-dependent responses appear to be able to survive throughout the life of mice and rats (Askonas et al. 1970, Gray et al. 1986). They can be transferred to syngeneic or congenic hosts where they again can dominate responses to the same antigen. Following transfer it is necessary to administer antigen to the recipient to initiate antibody production (Askonas and Williamson 1972, Siekevitz et al. 1987). Also, although transferred B cell memory will persist in the absence of antigen for a little over a month, after this period a response from the donor cells can no longer be elicited (Gray and Skarvall 1988).
KeywordsCell Clone Germinal Centre Follicular Dendritic Cell Established Phase Germinal Centre Reaction
Unable to display preview. Download preview PDF.
- Benner R. Hijmans W and Haaijman JJ (1981) Clin. Expt. Immunol. 46:1Google Scholar
- Gray D (1988) Immunol. 65:73Google Scholar
- Liu Y-J, joshua DE, Williams GT, Smith CE, Gordon J and MacLennan ICM submittedGoogle Scholar
- MacLennan ICM, Liu Y-J and Ling NR (1988) Current Topics in Microbiol. Immunol. 141:138.Google Scholar
- MacLennan ICM, Liu Y-J, Oldfield S, Zhang J and Lane P (1989) Current Topics in Microbiol and Immunol, in pressGoogle Scholar
- Tew JG and Mandel TE (1979) Immunol. 37:69Google Scholar