Selection of the T Cell Repertoire in the Thymus

  • J. W. Kappler
  • T. H. Finkel
  • P. Marrack


The T cell αβ receptor (αβTCR) generally recognizes a ligand composed of a fragment of antigen complexed to a product of the major histocompatibility complex (MHC). Although the precise nature of the binding of the receptor to its ligand is unknown the available data, including the recently solved structure of a human class I MHC molecule (Bjorkman et al. 1988), suggest a complex interaction in which the binding depends on the contact of residues in both the MHC and antigen portion of the ligand with the variable portion of the αβTCR. The polymorphic residues of the MHC molecule appear to be particularly important in this interaction because a particular βTCR which recognizes an antigen bound to one allelic form of an MHC molecule is unlikely to recognize the same antigen bound to a different allelic form of the MHC molecule. This phenomenon has been called “MHC restricted” antigen recognition.


Major Histocompatibility Complex Negative Selection Major Histocompatibility Complex Molecule Foreign Antigen Allelic Form 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bevan M (1977) Nature 269:417–419PubMedCrossRefGoogle Scholar
  2. Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC (1987) Nature 329:506–512PubMedCrossRefGoogle Scholar
  3. Carbone AM, Marrack P, Kappler JW (1988) Science 242:1174–1176PubMedCrossRefGoogle Scholar
  4. Farr AG, Anderson SK, Marrack P, Kappler J (1985) Cell 43:543–550PubMedCrossRefGoogle Scholar
  5. Finkel TH, Marrack P, Kappler J, Kubo R, Cambier J (1989) J. Immunol. 142:3006–3012PubMedGoogle Scholar
  6. Finkel TH, Cambier JC, Kubo RT, Born WK, Marrack P, Kappler JW (1989) Cell in pressGoogle Scholar
  7. Fowlkes BJ, Edison L, Mathieson B, Chused T (1985) J. Exp. Med. 162:802–822PubMedCrossRefGoogle Scholar
  8. Fowlkes BJ, Schwartz P, Pardoll D (1988) Nature 334:620–623PubMedCrossRefGoogle Scholar
  9. Jenkinson EJ, Jhittay P, Kingston R, Owen JJ (1984) Transplantation 39:331–333CrossRefGoogle Scholar
  10. Kappler J, Roehm N, Marrack P (1987) Cell 49:273–280PubMedCrossRefGoogle Scholar
  11. Kisielow P, Bluthmann H, Staerz UD, Steinmetz M, von Boehmer H (1988) Nature 333:742–746PubMedCrossRefGoogle Scholar
  12. Kisielow P, Teh H, Blüthmann H, von Boehmer H (1988) Nature 335:730–733PubMedCrossRefGoogle Scholar
  13. Kruisbeek AM, Mond JJ, Fowlkes BJ, Carmen JA, Bridges S, Longo DL (1985) J. Exp. Med. 161:1029–1049PubMedCrossRefGoogle Scholar
  14. Lo D, Ron Y, Sprent J (1986) Immunol. Res. 5:221–232PubMedCrossRefGoogle Scholar
  15. Lo D, Burkly L, Flavell RA, Palmiter RD, Brinster RL (1989) J. Exp. Med. 170:87–104PubMedCrossRefGoogle Scholar
  16. Marrack P, Lo D, Brinster R, Palmiter R, Burkly L, Flavell RH, Kappler JW (1988) Cell 53:627–634PubMedCrossRefGoogle Scholar
  17. McDuffie M, Born W, Marrack P, Kappler J (1986) Proc. Natl. Acad. Sei. USA 83:8728–8732CrossRefGoogle Scholar
  18. Mercep M, Bonifacino JS, Garcia-Morales P, Samelson LE, Klausner RD, Ashwell JD (1988) Science 242: 571–574PubMedCrossRefGoogle Scholar
  19. Smith L (1987) Nature 326:798–800PubMedCrossRefGoogle Scholar
  20. Samelson LE, Patel MD, Wiessman AM, Hartford JB, Klausner RD (1986) Cell 46:1083–1090PubMedCrossRefGoogle Scholar
  21. Scollay R, Shortman K (1984) Immunology Today 5:3CrossRefGoogle Scholar
  22. Sha W, Nelson C, Newberry R, Kranz D, Russell J, Loh D Nature 336:73–76Google Scholar
  23. Sprent J, Webb S (1987) Adv. Immunol. 41: 39–133PubMedCrossRefGoogle Scholar
  24. Weiss A, Imboden J, Shoback D, Stobo J (1984) Proc. Natl. Acad. Sei. USA 81:4169–4173CrossRefGoogle Scholar
  25. White J, Herman A, Pullen AM, Kubo R, Kappler J, Marrack P. Cell 56:27–35Google Scholar
  26. Zinkernagel R, Callahan G, Althage A, Cooper S, Klein P, Klein J (1978) J. Exp. Med. 147:882–896PubMedCrossRefGoogle Scholar
  27. Zúñiga-Pflücker JC, McCarthy SA, Weston M, Longo DL, Singer A, Kruisbeek AM (1989) J. Exp. Med. 169:2085–2096PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J. W. Kappler
  • T. H. Finkel
  • P. Marrack

There are no affiliations available

Personalised recommendations