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Production of Complement Component C3 by Lymphoid Cell Lines: Possible Function of C3 Fragments as Autocrine Growth Regulators

  • F. Salas
  • K. Kovats
  • S. Mathur
  • B. Sakamoto
  • M. R. Benitez
  • A. X. Delcayre
  • W. Lernhardt
Conference paper

Abstract

Complement component C3 synthesis by two human lymphoid cell lines was investigated at the mRNA and protein levels. We report that the C3 gene is constitutively transcribed and that C3 protein is synthesized, secreted and proteolytically processed in cell lines of the lymphoid lineage. Because C3 fragments are implicated in lymphocyte growth control, we will also discuss the significance of C3 fragments as potential autocrine growth regulators.

Keywords

Lymphoblastoid Cell Line Lymphoid Cell Line Complement Receptor Type Lymphoid Lineage Human Lymphoblastoid Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • F. Salas
  • K. Kovats
  • S. Mathur
  • B. Sakamoto
  • M. R. Benitez
  • A. X. Delcayre
  • W. Lernhardt

There are no affiliations available

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