Production of Complement Component C3 by Lymphoid Cell Lines: Possible Function of C3 Fragments as Autocrine Growth Regulators
Complement component C3 synthesis by two human lymphoid cell lines was investigated at the mRNA and protein levels. We report that the C3 gene is constitutively transcribed and that C3 protein is synthesized, secreted and proteolytically processed in cell lines of the lymphoid lineage. Because C3 fragments are implicated in lymphocyte growth control, we will also discuss the significance of C3 fragments as potential autocrine growth regulators.
KeywordsLymphoblastoid Cell Line Lymphoid Cell Line Complement Receptor Type Lymphoid Lineage Human Lymphoblastoid Cell Line
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